N-{1-[1-(2-phenylallyl)cyclopropyl]ethyl}-P,P-diphenylphosphinamide

Base Information

• Chemical Name: N-{1-[1-(2-phenylallyl)cyclopropyl]ethyl}-P,P-diphenylphosphinamide
• CAS No.: 758691-08-6
• Molecular Formula: C₂₆H₂₈NOP
• Molecular Weight: 401.488
• Mol file: 758691-08-6.mol

Synonyms:N-{1-[1-(2-phenylallyl)cyclopropyl]ethyl}-P,P-diphenylphosphinamide

Chemical Property of N-{1-[1-(2-phenylallyl)cyclopropyl]ethyl}-P,P-diphenylphosphinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{1-[1-(2-phenylallyl)cyclopropyl]ethyl}-P,P-diphenylphosphinamide

There total 1 articles about N-{1-[1-(2-phenylallyl)cyclopropyl]ethyl}-P,P-diphenylphosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

dimethyl zinc(II) (544-97-8) + (ICH2)2Zn dimethoxyethane complex + C22H20NOP → N-{1-[1-(2-phenylallyl)cyclopropyl]ethyl}-P,P-diphenylphosphinamide (758691-08-6)

Guidance literature:

dimethyl zinc(II); C₂₂H₂₀NOP; In dichloromethane; toluene; at 0 ℃; for 1h;

(ICH₂)2Zn dimethoxyethane complex; In dichloromethane; toluene; at 20 ℃; for 4h;

DOI:10.1021/ol0487783

Reference yield: 64.0%

N-{1-[1-(2-phenylallyl)cyclopropyl]ethyl}-P,P-diphenylphosphinamide (758691-08-6) → C26H28NO2P (758691-37-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 6.5h;

DOI:10.1021/ol0487783

Reference yield:

N-{1-[1-(2-phenylallyl)cyclopropyl]ethyl}-P,P-diphenylphosphinamide (758691-08-6) → (4S)-5-(diphenylphosphinoyl)-4-methyl-7-phenyl-5-azaspiro[2.5]octan-7-ol

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / m-CPBA / CH₂Cl₂ / 6.5 h / 20 °C

2: 57 percent / HMPA; NaH / tetrahydrofuran / 2.5 h / 70 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol0487783

upstream raw materials:

dimethyl zinc(II)

Downstream raw materials:

C₂₆H₂₈NO₂P