N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N₂-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide

Base Information

• Chemical Name: N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N₂-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide
• CAS No.: 1207079-17-1
• Molecular Formula: C₂₆H₂₃F₉N₄O₃S
• Molecular Weight: 642.545
• Mol file: 1207079-17-1.mol

Synonyms:N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N₂-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide

Chemical Property of N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N₂-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N₂-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide

There total 8 articles about N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N₂-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}aniline + 3-{[(1S)-1-methyl-2-(methylthio)ethyl]imino}-4-(trifluoromethoxy)-2-benzofuran-1(3H)-one (1207088-76-3) → N1-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N2-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide (1207079-17-1)

Guidance literature:

toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

4-{[3,5-bis(trifluoro-methyl)-1H-pyrazol-1-yl]methyl}-2-methylaniline (866638-67-7) + 3-{[(1S)-1-methyl-2-(methylthio)ethyl]imino}-4-(trifluoromethoxy)-2-benzofuran-1(3H)-one (1207088-76-3) → N1-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N2-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide (1207079-17-1)

Guidance literature:

toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid (1289644-82-1) → N1-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N2-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide (1207079-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; methyl chloroformate / water; ethyl acetate / 0.33 h / 50 °C

2: toluene-4-sulfonic acid / acetonitrile / 3 h / 20 °C

With sodium hydrogencarbonate; methyl chloroformate; toluene-4-sulfonic acid; In water; ethyl acetate; acetonitrile;

upstream raw materials:

3-{[(1S)-1-methyl-2-(methylthio)ethyl]imino}-4-(trifluoromethoxy)-2-benzofuran-1(3H)-one

3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid

2-trifluoromethoxy-benzoyl chloride

4-(chloromethyl)-2-methyl-1-nitro-benzene