3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid

Base Information

Chemical Name:3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid
CAS No.:1289644-82-1
Molecular Formula:C₁₃H₁₄F₃NO₄S
Molecular Weight:337.32
Hs Code.:

Synonyms:3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid

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Chemical Property of 3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid

Chemical Property:

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Technology Process of 3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid

There total 2 articles about 3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 1207088-75-2
N-[(1S)-1-methyl-2-(methylthio)ethyl]-2-(trifluoromethoxy)benzamide

: 1289644-82-1
3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid

Guidance literature:: N-[(1S)-1-methyl-2-(methylthio)ethyl]-2-(trifluoromethoxy)benzamide; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -70 ℃;

carbon dioxide; at -70 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; hexane; water;

Reference yield:

: 162046-61-9
2-trifluoromethoxy-benzoyl chloride

: 1289644-82-1
3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 1 h / 5 °C

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / -70 °C

2.2: 3 h / -70 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; triethylamine; In tetrahydrofuran; hexane;

Reference yield:

: 1289644-82-1
3-(trifluoromethoxy)-2-{[(1S)-1-methyl-2-(methylthio)ethyl]carbamoyl}benzoic acid

: 1207079-17-1
N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N₂-[(1S)-1-methyl-2-(methylthio)ethyl]-3-(trifluoromethoxy)-1,2-benzenedicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; methyl chloroformate / water; ethyl acetate / 0.33 h / 50 °C

2: toluene-4-sulfonic acid / acetonitrile / 3 h / 20 °C

With sodium hydrogencarbonate; methyl chloroformate; toluene-4-sulfonic acid; In water; ethyl acetate; acetonitrile;