C₁₈H₁₉NO₂Se

Base Information

Chemical Name:C₁₈H₁₉NO₂Se
CAS No.:261157-00-0
Molecular Formula:C₁₈H₁₉NO₂Se
Molecular Weight:360.314
Hs Code.:

C<sub>18</sub>H<sub>19</sub>NO<sub>2</sub>Se

Synonyms:C₁₈H₁₉NO₂Se

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Chemical Property of C₁₈H₁₉NO₂Se

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Technology Process of C₁₈H₁₉NO₂Se

There total 24 articles about C₁₈H₁₉NO₂Se which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 261156-91-6
(Diethoxy-phosphoryl)-acetic acid (1S,6R,7R)-8-oxo-9-phenylselanyl-2-aza-tricyclo[5.3.1.0^2,6]undec-7-yl ester

: 261157-00-0
C₁₈H₁₉NO₂Se

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In toluene; at 0 - 20 ℃;
DOI:10.1002/(SICI)1521-3773(20000103)39

Reference yield:

: 261156-79-0
(E)-3-[(2S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-acrylonitrile

: 261157-00-0
C₁₈H₁₉NO₂Se

Guidance literature:: Multi-step reaction with 17 steps

1.1: 98 percent / H₂ / Pd/C / ethyl acetate / 12 h / 760.05 Torr

2.1: 100 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

3.1: 84 percent / Jones reagent / acetone / 0.5 h / 20 °C

4.1: 78 percent / SmI₂; MeOH / tetrahydrofuran / -78 - 20 °C

5.1: 91 percent / DIPEA / CH₂Cl₂ / 17 h / 0 - 20 °C

6.1: 100 percent / p-TsOH*H₂O / benzene / 15 h / Heating

7.1: Na; naphthalene / 1,2-dimethoxy-ethane / 0.25 h / -78 °C

8.1: 1.2 g / DMAP / acetonitrile / 0 - 20 °C

9.1: NaNO₂; CuCl; HCl / methanol / 0.25 h / 20 °C

9.2: allyltrimethylsilane; BF₃*Et₂O / tetrahydrofuran; diethyl ether / -78 - -5 °C

10.1: 180 mg / Et₃N / CH₂Cl₂ / 14 h / Heating

11.1: BH₃*THF; 2-methyl-2-butene / tetrahydrofuran; diethyl ether / 0 - 20 °C

11.2: H₂O₂; aq. NaOH / tetrahydrofuran; diethyl ether / 0.83 h / 20 °C

12.1: 164 mg / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

13.1: 81 percent / HCl / methanol / 9 h / 60 °C

14.1: 74 percent / aq. HCl / 17 h / 95 °C

15.1: 60 percent / Et₃N / ethyl acetate / 48 h / 86 °C

16.1: 88 percent / CDC / CH₂Cl₂ / 0 - 20 °C

17.1: 95 percent / K₂CO₃; 18-crown-6 / toluene / 0 - 20 °C

With hydrogenchloride; methanol; dmap; jones reagent; samarium diiodide; borane-THF; 2-methyl-but-2-ene; naphthalene; 18-crown-6 ether; chenodeoxycholic acid; tetrabutyl ammonium fluoride; hydrogen; sodium; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) chloride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; ethyl acetate; acetone; toluene; acetonitrile; benzene; 1.1: Catalytic hydrogenation / 2.1: desilylation / 3.1: Oxidation / 4.1: Cyclization / 5.1: Condensation / 6.1: cyclocondensation / 7.1: Reduction / 8.1: Acylation / 9.1: Oxidation / 9.2: Substitution / 10.1: Acylation / 11.1: hydroboration / 11.2: Oxidation / 12.1: Tosylation / 13.1: Cyclization / 14.1: Hydrolysis / 15.1: Condensation / 16.1: Esterification / 17.1: Wadsworth-Horner-Emmons cyclization;
DOI:10.1021/jo000260z

Reference yield:

: 261156-80-3
3-[(R)-4-Oxo-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

: 261157-00-0
C₁₈H₁₉NO₂Se

Guidance literature:: Multi-step reaction with 14 steps

1.1: 78 percent / SmI₂; MeOH / tetrahydrofuran / -78 - 20 °C

2.1: 91 percent / DIPEA / CH₂Cl₂ / 17 h / 0 - 20 °C

3.1: 100 percent / p-TsOH*H₂O / benzene / 15 h / Heating

4.1: Na; naphthalene / 1,2-dimethoxy-ethane / 0.25 h / -78 °C

5.1: 1.2 g / DMAP / acetonitrile / 0 - 20 °C

6.1: NaNO₂; CuCl; HCl / methanol / 0.25 h / 20 °C

6.2: allyltrimethylsilane; BF₃*Et₂O / tetrahydrofuran; diethyl ether / -78 - -5 °C

7.1: 180 mg / Et₃N / CH₂Cl₂ / 14 h / Heating

8.1: BH₃*THF; 2-methyl-2-butene / tetrahydrofuran; diethyl ether / 0 - 20 °C

8.2: H₂O₂; aq. NaOH / tetrahydrofuran; diethyl ether / 0.83 h / 20 °C

9.1: 164 mg / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

10.1: 81 percent / HCl / methanol / 9 h / 60 °C

11.1: 74 percent / aq. HCl / 17 h / 95 °C

12.1: 60 percent / Et₃N / ethyl acetate / 48 h / 86 °C

13.1: 88 percent / CDC / CH₂Cl₂ / 0 - 20 °C

14.1: 95 percent / K₂CO₃; 18-crown-6 / toluene / 0 - 20 °C

With hydrogenchloride; methanol; dmap; samarium diiodide; borane-THF; 2-methyl-but-2-ene; naphthalene; 18-crown-6 ether; chenodeoxycholic acid; sodium; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) chloride; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; ethyl acetate; toluene; acetonitrile; benzene; 1.1: Cyclization / 2.1: Condensation / 3.1: cyclocondensation / 4.1: Reduction / 5.1: Acylation / 6.1: Oxidation / 6.2: Substitution / 7.1: Acylation / 8.1: hydroboration / 8.2: Oxidation / 9.1: Tosylation / 10.1: Cyclization / 11.1: Hydrolysis / 12.1: Condensation / 13.1: Esterification / 14.1: Wadsworth-Horner-Emmons cyclization;
DOI:10.1021/jo000260z