N`-[(3,4-dimethoxyphenyl)-methylidene]-2-cyanoacetohydrazide

Base Information

• Chemical Name: N`-[(3,4-dimethoxyphenyl)-methylidene]-2-cyanoacetohydrazide
• CAS No.: 88614-67-9
• Molecular Formula: C₁₂H₁₃N₃O₃
• Molecular Weight: 247.254
• Mol file: 88614-67-9.mol

Synonyms:N`-[(3,4-dimethoxyphenyl)-methylidene]-2-cyanoacetohydrazide

Chemical Property of N`-[(3,4-dimethoxyphenyl)-methylidene]-2-cyanoacetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N`-[(3,4-dimethoxyphenyl)-methylidene]-2-cyanoacetohydrazide

There total 3 articles about N`-[(3,4-dimethoxyphenyl)-methylidene]-2-cyanoacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

Cyanoacetohydrazide (140-87-4) + 2-acetyl-3-(3,4-dimethoxyphenyl)-1-methylpropenone (86213-22-1) → N`-[(3,4-dimethoxyphenyl)-methylidene]-2-cyanoacetohydrazide (88614-67-9) + 4-(3,4-dimethoxybenzylidene)-4,7-dihydro-3,5-dimethyl-7-oxo-1H-1,2-diazepine-6-carbonitrile (127382-01-8)

Guidance literature:

With piperidine; In ethanol; for 3h; Ambient temperature;

Reference yield:

Cyanoacetohydrazide (140-87-4) + 3,4-dimethoxy-benzaldehyde (120-14-9) → N`-[(3,4-dimethoxyphenyl)-methylidene]-2-cyanoacetohydrazide (88614-67-9)

Guidance literature:

With acetic acid; In ethanol; Microwave irradiation;

DOI:10.13005/ojc/320350

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → N`-[(3,4-dimethoxyphenyl)-methylidene]-2-cyanoacetohydrazide (88614-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: caproic acid, piperidine

2: 82 percent / piperidine / ethanol / 3 h / Ambient temperature

With piperidine; hexanoic acid; In ethanol;

upstream raw materials:

Cyanoacetohydrazide

2-acetyl-3-(3,4-dimethoxyphenyl)-1-methylpropenone

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

dimethyl 5-cyano-4-(cyclohexylamino)-1-(3,4-dimethoxybenzylideneamino)-6-oxo-1,2,5,6-tetrahydropyridine-2,3-dicarboxylate

(E)-1-((3,4-dimethoxybenzylidene)amino)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile