benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

Base Information

Chemical Name:benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate
CAS No.:1222891-39-5
Molecular Formula:C₂₃H₂₅FN₂O₄
Molecular Weight:412.461
Hs Code.:

Synonyms:benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

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Chemical Property of benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

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Technology Process of benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

There total 7 articles about benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1227685-11-1
benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

: 1222891-39-5
benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo400016m

Reference yield:

: 1227779-65-8
C₁₅H₁₇FN₂O₂

: 1222891-39-5
benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; tetrahydrofuran / 9 h / 0 °C

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo400016m

Reference yield:

: 921599-74-8,852051-10-6
benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

: 1222891-39-5
benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / 18 h / 20 °C / Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: sodium ethanolate / ethanol / 0.75 h / 20 °C / Inert atmosphere

4: hydrogenchloride / water / 28 h / Inert atmosphere; Reflux

5: sodium hydroxide / water; tetrahydrofuran / 9 h / 0 °C

6: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; sodium ethanolate; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1: |Strecker Aminoacid Synthesis;
DOI:10.1021/jo400016m