benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

Base Information

• Chemical Name: benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate
• CAS No.: 1227685-11-1
• Molecular Formula: C₂₃H₂₃FN₂O₄
• Molecular Weight: 410.445

Synonyms:benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

Chemical Property of benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

There total 17 articles about benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C26H26FN2O6(1-)*Na(1+) → benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate (1227685-11-1)

Guidance literature:

With hydrogenchloride; In 2-methyltetrahydrofuran; water; for 1h; Reflux;

DOI:10.1021/op400115g

Reference yield:

(5R,7S)-1-(3-fluorophenyl)-7-methyl-1,8-diazaspiro[4.5]decane-2,4-dione hydrochloride (1227685-10-0) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate (1227685-11-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 4h;

Reference yield:

8-benzyl 3-ethyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate (1416161-83-5) → benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate (1227685-11-1)

Guidance literature:

With water; In 2-methyltetrahydrofuran; Reflux;

upstream raw materials:

(5R,7S)-1-(3-fluorophenyl)-7-methyl-1,8-diazaspiro[4.5]decane-2,4-dione hydrochloride

benzyl chloroformate

3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester

4-methoxypyridine

Downstream raw materials:

(5R,7S)-benzyl 1-(3-fluorophenyl)-7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

(5R,7S)-1-(3-fluorophenyl)-8-[4-hydroxy-3-(5-methyl-1H-pyrazol-1-yl)benzyl]-7-methyl-1,8-diazaspiro[4.5]dec-3-en-2-one

benzyl 1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

(5R,7S)-1-(3-fluorophenyl)-7-methyl-1,8-diazaspiro[4.5]dec-3-en-2-one

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