(R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester

Base Information

Chemical Name:(R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester
CAS No.:66854-34-0
Molecular Formula:C₁₇H₂₁N₃O₃S
Molecular Weight:347.438
Hs Code.:

Synonyms:(R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester

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Chemical Property of (R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester

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Technology Process of (R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester

There total 5 articles about (R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1138161-40-6
(R)-3-[(2S,3S)-2-azido-3-phenylbutyrylamino]-3-(thiazol-2-yl)propionic acid methyl ester

: 66854-34-0
(R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1h;
DOI:10.1002/anie.200804138

Reference yield:

: 15005-62-6
bottromycin A₂

: 66854-34-0
(R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester

: 1138161-35-9
C₂₅H₄₁N₅O₄

Guidance literature:: In methanol; at 130 ℃; for 3h;
DOI:10.1002/anie.200804138

Reference yield:

: 1138161-39-3
(S(S),R)-methyl N-(p-toluenesulfinyl)-3-amino-3-(thiazol-2-yl)propanoate

: 66854-34-0
(R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / methanol

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

3: palladium on activated charcoal; hydrogen / methanol

With palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/acs.joc.8b00045