N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

Base Information

Chemical Name:N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester
CAS No.:1138161-43-9
Molecular Formula:C₅₅H₆₈N₆O₇SSi
Molecular Weight:985.332
Hs Code.:

N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

Synonyms:N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

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Chemical Property of N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

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Technology Process of N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

There total 8 articles about N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1138161-41-7
N-{L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

: 1138161-42-8
N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide

: 1138161-43-9
N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

Guidance literature:: With 2,6-dimethylpyridine; Hg(OTf)2; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1002/anie.200804138

Reference yield: 77.0%

: 1138161-41-7
N-{L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

: 1138161-42-8
N-phthaloyl-L-tert-leucine 2-tert-butyldiphenylsilyloxyethylthioamide

: 1138161-43-9
N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

: C₃₂H₃₈N₂O₄Si

Guidance literature:: With mercuric triflate; triethylamine; In acetonitrile; Reagent/catalyst; Solvent;
DOI:10.1021/acs.joc.8b00045

Reference yield:

: 66854-34-0
(R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester

: 1138161-43-9
N-{[N-phthaloyl-L-(2-tert-butyldiphenylsilyloxyethyl)imino-tert-leucyl]-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate / dichloromethane; N,N-dimethyl-formamide

2: hydrogenchloride / water; 1,4-dioxane

3: mercuric triflate; 2,6-dimethylpyridine / acetonitrile

With 2,6-dimethylpyridine; hydrogenchloride; mercuric triflate; N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.joc.8b00045