N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Base Information

Chemical Name:N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide
CAS No.:1403479-48-0
Molecular Formula:C₂₉H₄₃FN₄O₅S
Molecular Weight:578.749
Hs Code.:

N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Synonyms:N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

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Chemical Property of N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

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Technology Process of N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

There total 20 articles about N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1403479-46-8
N-(((8R,9R,15S)-8,15-dimethyl-6-((2S)-1-(methylamino)propan-2-yl)-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

: 1403479-48-0
N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: formaldehyd; N-(((8R,9R,15S)-8,15-dimethyl-6-((2S)-1-(methylamino)propan-2-yl)-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide; With magnesium sulfate; In dichloromethane; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 18h;
DOI:10.1021/jm500994n

Reference yield:

: 4-fluoro-N-{[(8R,9R,15S)-6-[(2S)-1-hydroxypropan-2-yl]-8,15-dimethyI-5-oxo-5H,6H,7H,8H,9H,11H,12H,13H,14H,15H-pyrido[2,3-b]1,9-dioxa-5-azacyclotetradecan-9-yl]methyl}-N-methylbenzene-1-sulfonamide

: 1403479-48-0
N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.25 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

4: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 1.5 h / 20 °C

5: magnesium sulfate / dichloromethane / 1 h

With di-isopropyl azodicarboxylate; magnesium sulfate; potassium carbonate; thiophenol; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: tert-butyl ((S)-2-((8R,9R,15S)-9-((4-fluoro-N-methylphenylsulfonamido)methyl)-8,15-dimethyl-5-oxo-8,9,12,13,14,15-hexahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-6(5H,7H,11H)-yl)propyl)((2-nitrophenyl)sulfonyl)carbamate

: 1403479-48-0
N-(((8R,9R,15S)-6-((2S)-1-(dimethylamino)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

3: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 1.5 h / 20 °C

4: magnesium sulfate / dichloromethane / 1 h

With magnesium sulfate; potassium carbonate; thiophenol; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;