isopropyl benzylmethylphosphinate

Base Information

• Chemical Name: isopropyl benzylmethylphosphinate
• CAS No.: 85185-99-5
• Molecular Formula: C₁₁H₁₇O₂P
• Molecular Weight: 212.229
• Mol file: 85185-99-5.mol

Synonyms:isopropyl benzylmethylphosphinate

Chemical Property of isopropyl benzylmethylphosphinate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of isopropyl benzylmethylphosphinate

There total 5 articles about isopropyl benzylmethylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

isopropyl benzyl-H-phosphinate (123691-76-9) + methyl iodide (74-88-4) → isopropyl benzylmethylphosphinate (85185-99-5)

Guidance literature:

With sodium isopropylate; In tetrahydrofuran; isopropyl alcohol; Ambient temperature;

DOI:10.1080/10426509608037971

Reference yield: 42.0%

S-methyl O-isopropyl methylphosphonothioate (120394-30-1) + benzylmagnesium chloride (6921-34-2) → dibenzyl-methyl-phosphine oxide (92556-44-0) + (-)-(S)-isopropyl methylbenzylphosphonate (85185-99-5) + 1,1'-(1,2-ethanediyl)bisbenzene (103-29-7)

Guidance literature:

In diethyl ether; toluene; for 8h; Heating;

DOI:10.1021/ja00352a035

Reference yield: 42.0%

S-methyl O-isopropyl methylphosphonothioate (120394-30-1) + benzylmagnesium chloride (6921-34-2) → (-)-(S)-isopropyl methylbenzylphosphonate (85185-99-5)

Guidance literature:

In diethyl ether; toluene; for 8h; Heating;

DOI:10.1016/S0040-4039(00)85650-6

upstream raw materials:

S-methyl O-isopropyl methylphosphonothioate

benzylmagnesium chloride

Methyl-phosphonothioic acid S-[2-(2-ethoxy-ethoxy)-ethyl] ester O-isopropyl ester

isopropyl benzyl-H-phosphinate

Downstream raw materials:

n-propylmethylbenzylphosphine

Benzyl-ethyl-methyl-phosphinoxid

n-propylmethylbenzylphosphinoxide

Refernces

• 1、 Gallagher, Michael J.,Ranasinghe, Millagahamada G.,Jenkins, Ian D.. "Mono-and dialkylation of isopropyl phosphinate - A simple preparation of alkylphosphinate esters1". . p. 255 - 259. Retrieved 2007/10/03.