2-benzyl-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine

Base Information

• Chemical Name: 2-benzyl-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine
• CAS No.: 26685-47-2
• Molecular Formula: C₃₀H₄₁NO₂
• Molecular Weight: 447.661
• Mol file: 26685-47-2.mol

Synonyms:2-benzyl-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine

Chemical Property of 2-benzyl-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzyl-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine

There total 15 articles about 2-benzyl-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-[1-benzyl-4-(1-hydroxy-1-methyl-ethyl)-1,2,5,6-tetrahydro-pyridin-3-yl]-5-(1,2-dimethyl-heptyl)-benzene-1,3-diol (271242-28-5) → 2-benzyl-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine (26685-47-2)

Guidance literature:

With toluene-4-sulfonic acid; In methoxybenzene; at 60 ℃;

Reference yield:

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (52763-21-0) → 2-benzyl-8-(1,2-dimethyl-heptyl)-5,5-dimethyl-1,3,4,5-tetrahydro-2H-chromeno[4,3-c]pyridin-10-ol (26685-47-2,58020-01-2,58020-02-3,58020-03-4,58020-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄, POCl₃

With sulfuric acid; trichlorophosphate;

DOI:10.1021/jm00226a001

Reference yield:

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (52763-21-0) → 2-benzyl-8-(1,2-dimethyl-heptyl)-5,5-dimethyl-1,3,4,5-tetrahydro-2H-chromeno[4,3-c]pyridin-10-ol (26685-47-2,58020-01-2,58020-02-3,58020-03-4,58020-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄, POCl₃

With sulfuric acid; trichlorophosphate;

DOI:10.1021/jm00226a001

upstream raw materials:

2-benzyl-8-(1,2-dimethylheptyl)-10-hydroxy-5-oxo-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine

methyl magnesium iodide

2-[1-benzyl-4-(1-hydroxy-1-methyl-ethyl)-1,2,5,6-tetrahydro-pyridin-3-yl]-5-(1,2-dimethyl-heptyl)-benzene-1,3-diol

2-benzyl-8-(1,2-dimethyl-heptyl)-10-hydroxy-1,2,3,4-tetrahydro-chromeno[4,3-c]pyridin-5-one

Downstream raw materials:

5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine

SP 1

10-acetoxy-2-allyl-8-(1,2-dimethyl-heptyl)-5,5-dimethyl-1,3,4,5-tetrahydro-2H-chromeno[4,3-c]pyridine

2-cyclobutylmethyl-8-(1,2-dimethyl-heptyl)-5,5-dimethyl-1,3,4,5-tetrahydro-2H-chromeno[4,3-c]pyridin-10-ol