Technology Process of N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine
There total 10 articles about N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate;
2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex;
In
1,4-dioxane; water;
at 100 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 5 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere
With
potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; sodium hydride;
In
1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;
2.1: Suzuki coupling;
DOI:10.1021/jm100659v
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 90 °C / Inert atmosphere
2: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
3: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; potassium acetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;
In
1,4-dioxane; water; dimethyl sulfoxide; toluene;
1: Buchwald-Hartwig amination / 2: Suzuki-Miyura coupling / 3: Suzuki coupling;
DOI:10.1021/jm100659v
