N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine

Base Information

Chemical Name:N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine
CAS No.:1097832-00-2
Molecular Formula:C₃₂H₃₆N₄O₃Si
Molecular Weight:552.748
Hs Code.:

Synonyms:N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine

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Chemical Property of N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine

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Technology Process of N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine

There total 10 articles about N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 915411-18-6
4-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole

: 915410-97-8
N-(3-(4-methoxybenzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridin-3-amine

: 1097832-00-2
N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine

Guidance literature:: With potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; In 1,4-dioxane; water; at 100 ℃; for 5h;

Reference yield:

: 186407-74-9
4-bromoindazole

: 1097832-00-2
N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 5 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere

With potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; sodium hydride; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 2.1: Suzuki coupling;
DOI:10.1021/jm100659v

Reference yield:

: 915410-93-4
1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene

: 1097832-00-2
N-(3-(4-methoxybenzyloxy)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-4-yl)phenyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 90 °C / Inert atmosphere

2: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

3: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; potassium acetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In 1,4-dioxane; water; dimethyl sulfoxide; toluene; 1: Buchwald-Hartwig amination / 2: Suzuki-Miyura coupling / 3: Suzuki coupling;
DOI:10.1021/jm100659v