Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester

Base Information

• Chemical Name: Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester
• CAS No.: 193279-86-6
• Molecular Formula: C₃₈H₄₈O₉S
• Molecular Weight: 680.86

Synonyms:Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester

Chemical Property of Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester

There total 20 articles about Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(4aS,6R,7S,9S,10aR)-6-[4-(2-Ethoxy-ethoxy)-but-2-ynyl]-2,2,9-trimethyl-hexahydro-1,3,5-trioxa-benzocycloocten-7-yloxy}-triisopropyl-silane (1054689-67-6) → Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester (193279-86-6)

Guidance literature:

Multi-step reaction with 13 steps

1: PPTS / propan-1-ol

2: Red-Al / diethyl ether

3: 97 percent / (D)-(-)-diethyl tartrate, Ti(O(i-Pr))4, t-BuOOH, 4 Angstroem molecular sieves / CH₂Cl₂ / -20 °C

4: SO₃-pyridine, Et₃N, DMSO / 1,2-dichloro-ethane

5: toluene

6: Bu₄NF / tetrahydrofuran

7: Pd(PPh₃)4, PPh₃ / CH₂Cl₂ / 0.08 h

8: 98 percent / DIBAL-H / CH₂Cl₂ / -78 °C

9: 92 percent / NaH / dimethylformamide; tetrahydrofuran / 0 °C

10: p-MeC₆H₄SO₃H*H₂O / methanol

11: PPTS / 1,2-dichloro-ethane

12: 97 percent / DIBAL-H / CH₂Cl₂ / -40 °C

13: Et₃N / CH₂Cl₂ / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; pyridine-SO₃ complex; diethyl (2S,3S)-tartrate; 4 A molecular sieve; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; methanol; propan-1-ol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

DOI:10.1039/a702158e

Reference yield:

((4aS,6R,7S,9S,10aR)-6-Benzyloxymethoxymethyl-2,2,9-trimethyl-hexahydro-1,3,5-trioxa-benzocycloocten-7-yloxy)-triisopropyl-silane (193279-67-3) → Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester (193279-86-6)

Guidance literature:

Multi-step reaction with 16 steps

1: 87 percent / H₂ / Pd(OH)2/C / ethyl acetate

2: Et₃N / 1,2-dichloro-ethane / -15 °C

3: BuLi / tetrahydrofuran; various solvent(s) / -78 °C

4: PPTS / propan-1-ol

5: Red-Al / diethyl ether

6: 97 percent / (D)-(-)-diethyl tartrate, Ti(O(i-Pr))4, t-BuOOH, 4 Angstroem molecular sieves / CH₂Cl₂ / -20 °C

7: SO₃-pyridine, Et₃N, DMSO / 1,2-dichloro-ethane

8: toluene

9: Bu₄NF / tetrahydrofuran

10: Pd(PPh₃)4, PPh₃ / CH₂Cl₂ / 0.08 h

11: 98 percent / DIBAL-H / CH₂Cl₂ / -78 °C

12: 92 percent / NaH / dimethylformamide; tetrahydrofuran / 0 °C

13: p-MeC₆H₄SO₃H*H₂O / methanol

14: PPTS / 1,2-dichloro-ethane

15: 97 percent / DIBAL-H / CH₂Cl₂ / -40 °C

16: Et₃N / CH₂Cl₂ / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; pyridine-SO₃ complex; diethyl (2S,3S)-tartrate; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; methanol; propan-1-ol; diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

DOI:10.1039/a702158e

Reference yield:

(E)-3-[(2R,3R)-3-((4aS,6R,7S,9S,10aR)-2,2,9-Trimethyl-7-triisopropylsilanyloxy-hexahydro-1,3,5-trioxa-benzocycloocten-6-ylmethyl)-oxiranyl]-acrylic acid methyl ester (193279-71-9) → Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester (193279-86-6)

Guidance literature:

Multi-step reaction with 8 steps

1: Bu₄NF / tetrahydrofuran

2: Pd(PPh₃)4, PPh₃ / CH₂Cl₂ / 0.08 h

3: 98 percent / DIBAL-H / CH₂Cl₂ / -78 °C

4: 92 percent / NaH / dimethylformamide; tetrahydrofuran / 0 °C

5: p-MeC₆H₄SO₃H*H₂O / methanol

6: PPTS / 1,2-dichloro-ethane

7: 97 percent / DIBAL-H / CH₂Cl₂ / -40 °C

8: Et₃N / CH₂Cl₂ / 0 °C

With tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1039/a702158e

upstream raw materials:

methanesulfonyl chloride

[(2R,3R,4aR,6S,7R,9S,10aS)-3-Benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-yl]-methanol

{(4aS,6R,7S,9S,10aR)-6-[4-(2-Ethoxy-ethoxy)-but-2-ynyl]-2,2,9-trimethyl-hexahydro-1,3,5-trioxa-benzocycloocten-7-yloxy}-triisopropyl-silane

((4aS,6R,7S,9S,10aR)-6-Benzyloxymethoxymethyl-2,2,9-trimethyl-hexahydro-1,3,5-trioxa-benzocycloocten-7-yloxy)-triisopropyl-silane

Downstream raw materials:

[(2R,3R,4aR,6S,7R,9S,10aS)-3-Benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-yl]-acetonitrile

(E)-4-[(2R,3R,4aR,6S,7R,9S,10aS)-3-Benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-yl]-2-methyl-but-2-enoic acid ethyl ester

(2R,3R,4aR,6S,7R,9S,10aS)-3-Benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-6-((2R,3R)-3-methyl-3-vinyl-oxiranylmethyl)-decahydro-1,5-dioxa-benzocyclooctene

{(2R,3R)-3-[(2R,3R,4aR,6S,7R,9S,10aS)-3-Benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl]-2-methyl-oxiranyl}-methanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 193279-86-6 Methanesulfonic acid (2R,3R,4aR,6S,7R,9S,10aS)-3-benzyloxy-2-((E)-3-benzyloxy-propenyl)-7-(4-methoxy-benzyloxy)-9-methyl-decahydro-1,5-dioxa-benzocycloocten-6-ylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send