1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

Base Information

Chemical Name:1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid
CAS No.:1372540-14-1
Molecular Formula:C₂₀H₁₉Cl₂N₃O₃
Molecular Weight:420.295
Hs Code.:

Synonyms:1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

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Chemical Property of 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

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Technology Process of 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

There total 9 articles about 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372540-15-2
methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

: 1372540-14-1
1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

: 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid monohydrochloride

Guidance literature:: methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

: 84752-20-5
4-bromo-6-nitro-1,2-phenylenediamine

: 1372540-14-1
1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

: 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid monohydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol; water / 3 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

4.1: water; iron(II) sulfate; iron / ethanol / 3 h / Reflux

5.1: sodium nitrite; hydrogen bromide / water / 0.25 h / 0 - 5 °C

5.2: 0.5 h / 60 - 80 °C

5.3: 20 °C

6.1: triethylamine / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 60 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

7.2: 1 h / 20 °C

With water; hydrogen bromide; iron; potassium carbonate; caesium carbonate; iron(II) sulfate; triethylamine; lithium hydroxide; sodium nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 62554-90-9
4-bromo-2,6-dinitroaniline

: 1372540-14-1
1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

: 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid monohydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: diammonium sulfide / ethanol / 2 h / 90 °C

2.1: ethanol; water / 3 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

4.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

5.1: water; iron(II) sulfate; iron / ethanol / 3 h / Reflux

6.1: sodium nitrite; hydrogen bromide / water / 0.25 h / 0 - 5 °C

6.2: 0.5 h / 60 - 80 °C

6.3: 20 °C

7.1: triethylamine / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 60 °C

8.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

8.2: 1 h / 20 °C

With diammonium sulfide; water; hydrogen bromide; iron; potassium carbonate; caesium carbonate; iron(II) sulfate; triethylamine; lithium hydroxide; sodium nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;