methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

Base Information

Chemical Name:methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate
CAS No.:1372540-15-2
Molecular Formula:C₂₁H₂₁Cl₂N₃O₃
Molecular Weight:434.322
Hs Code.:

Synonyms:methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

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Chemical Property of methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

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Technology Process of methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

There total 7 articles about methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 606-22-4
2,6-dinitroaniline

: 1372540-15-2
methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: bromine / acetic acid / 2 h / 120 °C

2.1: diammonium sulfide / ethanol / 2 h / 90 °C

3.1: ethanol; water / 3 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

5.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

6.1: water; iron(II) sulfate; iron / ethanol / 3 h / Reflux

7.1: sodium nitrite; hydrogen bromide / water / 0.25 h / 0 - 5 °C

7.2: 0.5 h / 60 - 80 °C

7.3: 20 °C

8.1: triethylamine / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 60 °C

With diammonium sulfide; water; hydrogen bromide; bromine; iron; potassium carbonate; caesium carbonate; iron(II) sulfate; triethylamine; sodium nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; XPhos; In 1,4-dioxane; ethanol; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 84752-20-5
4-bromo-6-nitro-1,2-phenylenediamine

: 1372540-15-2
methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol; water / 3 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

4.1: water; iron(II) sulfate; iron / ethanol / 3 h / Reflux

5.1: sodium nitrite; hydrogen bromide / water / 0.25 h / 0 - 5 °C

5.2: 0.5 h / 60 - 80 °C

5.3: 20 °C

6.1: triethylamine / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 60 °C

With water; hydrogen bromide; iron; potassium carbonate; caesium carbonate; iron(II) sulfate; triethylamine; sodium nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; XPhos; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 62554-90-9
4-bromo-2,6-dinitroaniline

: 1372540-15-2
methyl 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diammonium sulfide / ethanol / 2 h / 90 °C

2.1: ethanol; water / 3 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

4.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

5.1: water; iron(II) sulfate; iron / ethanol / 3 h / Reflux

6.1: sodium nitrite; hydrogen bromide / water / 0.25 h / 0 - 5 °C

6.2: 0.5 h / 60 - 80 °C

6.3: 20 °C

7.1: triethylamine / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 60 °C

With diammonium sulfide; water; hydrogen bromide; iron; potassium carbonate; caesium carbonate; iron(II) sulfate; triethylamine; sodium nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; XPhos; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;