trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

Base Information

Chemical Name:trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride
CAS No.:945997-76-2
Molecular Formula:C₃₂H₃₂ClF₃N₂O₂S*ClH
Molecular Weight:637.593
Hs Code.:

trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

Synonyms:trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

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Chemical Property of trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

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Technology Process of trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

There total 6 articles about trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21815-91-8
3-chlorobenzo[b]thiophen-2-carbonyl chloride

: C₂₃H₂₉F₃N₂O

: 945997-76-2
trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

Guidance literature:: 3-chlorobenzo[b]thiophen-2-carbonyl chloride; C₂₃H₂₉F₃N₂O; In dichloromethane; at 20 ℃; for 16h;

With hydrogenchloride; In ethanol; water; at 20 ℃; for 16h;

Reference yield:

: 15803-59-5,1932261-28-3,38362-02-6
(1r,4r)-N¹-methylcyclohexane-1,4-diamine

: 945997-76-2
trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzaldehyde / toluene / 6 h / Heating / reflux

1.2: 3.25 h / 20 °C

2.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

2.2: 16 h / 20 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 16.08 h / 80 °C

4.1: bicarbonate resin / dichloromethane / 16 h / 20 °C

4.2: 16 h / 20 °C

With caesium carbonate; benzaldehyde; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 566172-79-0
trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane

: 945997-76-2
trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4-ethoxy-4'-trifluoromethyl-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

1.2: 16 h / 20 °C

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 16.08 h / 80 °C

3.1: bicarbonate resin / dichloromethane / 16 h / 20 °C

3.2: 16 h / 20 °C

With caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;