N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

Base Information

Chemical Name:N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide
CAS No.:1301660-43-4
Molecular Formula:C₃₁H₃₀F₇N₃O₄
Molecular Weight:641.586
Hs Code.:

N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

Synonyms:N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

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Chemical Property of N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

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Technology Process of N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

There total 9 articles about N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1301660-98-9
1,1-dimethylethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,3-bis(hydroxymethyl)-2-oxo-1-pyrrolidinecarboxylate

: 1301660-43-4
N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-43-4
N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

5.1: hydrogen / Raney-Ni / ethanol; water / 4 h

6.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

7.1: n-butyllithium / tetrahydrofuran / 0.5 h / -15 °C

7.2: 1 h / -15 °C

8.1: calcium chloride; sodium tetrahydroborate / ethanol / 2 h / 0 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dmap; sodium tetrahydroborate; osmium(VIII) oxide; n-butyllithium; water; hydrogen; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; calcium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-56-9
2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-formyl-3-pyridinyl]-N,2-dimethylpropanamide

: 1301660-43-4
N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 2 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

3.1: hydrogen / Raney-Ni / ethanol; water / 4 h

4.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -15 °C

5.2: 1 h / -15 °C

6.1: calcium chloride; sodium tetrahydroborate / ethanol / 2 h / 0 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dmap; sodium tetrahydroborate; n-butyllithium; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; calcium chloride; Raney-Ni; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;