2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester

Base Information

Chemical Name:2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester
CAS No.:765243-11-6
Molecular Formula:C₂₀H₂₃ClN₂O₅S
Molecular Weight:438.932
Hs Code.:

Synonyms:2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester

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Chemical Property of 2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester

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Technology Process of 2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester

There total 3 articles about 2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 108877-03-8
ethyl 2-acetamido-4-ethoxycarbonyl-4-thiocarbamoylbutanoate

: 536-38-9
4-chlorobenzoylmethyl bromide

: 765243-11-6
2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester

Guidance literature:: In ethanol; Heating;
DOI:10.1016/0223-5234(93)90125-X

Reference yield:

: 5440-42-6
ethyl 2-acetamido-4-cyano-2-ethoxycarbonylbutanoate

: 765243-11-6
2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / H₂S, Et₃N, pyridine / 1.5 h / 100 °C

2: 83 percent / ethanol / Heating

With pyridine; hydrogen sulfide; triethylamine; In ethanol;
DOI:10.1016/0223-5234(93)90125-X

Reference yield:

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 765243-11-6
2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: EtONa

2: 50 percent / H₂S, Et₃N, pyridine / 1.5 h / 100 °C

3: 83 percent / ethanol / Heating

With pyridine; hydrogen sulfide; sodium ethanolate; triethylamine; In ethanol;
DOI:10.1016/0223-5234(93)90125-X