2-methyl-5-nitro-N,4,6-triphenyl-1,4-dihydropyridine-3-carboxamide

Base Information

• Chemical Name: 2-methyl-5-nitro-N,4,6-triphenyl-1,4-dihydropyridine-3-carboxamide
• CAS No.: 900186-60-9
• Molecular Formula: C₂₅H₂₁N₃O₃
• Molecular Weight: 411.46
• Mol file: 900186-60-9.mol

Synonyms:2-methyl-5-nitro-N,4,6-triphenyl-1,4-dihydropyridine-3-carboxamide

Chemical Property of 2-methyl-5-nitro-N,4,6-triphenyl-1,4-dihydropyridine-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-5-nitro-N,4,6-triphenyl-1,4-dihydropyridine-3-carboxamide

There total 1 articles about 2-methyl-5-nitro-N,4,6-triphenyl-1,4-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(Z)-2-nitro-1,3-diphenylprop-2-en-1-one (18315-85-0) + (E)-3-Amino-but-2-enoic acid phenylamide → 2-methyl-5-nitro-N,4,6-triphenyl-1,4-dihydropyridine-3-carboxamide (900186-60-9)

Guidance literature:

With acetic acid; at 20 ℃;

DOI:10.1007/s10593-005-0214-4

Reference yield: 80.0%

2-methyl-5-nitro-N,4,6-triphenyl-1,4-dihydropyridine-3-carboxamide (900186-60-9) → 2-methyl-5-nitro-N,4,6-triphenylnicotinamide (900186-67-6)

Guidance literature:

With acetic acid; sodium nitrite; at 60 - 70 ℃; for 1h;

DOI:10.1007/s10593-005-0214-4

Reference yield:

2-methyl-5-nitro-N,4,6-triphenyl-1,4-dihydropyridine-3-carboxamide (900186-60-9) → 1,2-dimethyl-5-nitro-N,4,6-triphenylnicotinamide methylsulfate

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / sodium nitrite / acetic acid / 1 h / 60 - 70 °C

2: 96 percent / pyridine / 10 h / 100 °C

With pyridine; sodium nitrite; In acetic acid;

DOI:10.1134/S1070428006080173

upstream raw materials:

(Z)-2-nitro-1,3-diphenylprop-2-en-1-one

Downstream raw materials:

2-methyl-5-nitro-N,4,6-triphenylnicotinamide