3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine

Base Information

Chemical Name:3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine
CAS No.:1417910-38-3
Molecular Formula:C₂₃H₁₈ClN₅
Molecular Weight:399.882
Hs Code.:

Synonyms:3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine

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Chemical Property of 3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine

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Technology Process of 3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine

There total 7 articles about 3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 10147-11-2
propargyl benzene

: 1417910-24-7
C₁₄H₁₀ClN₅

: 1417910-38-3
3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine

Guidance literature:: With copper(l) iodide; In water; at 20 ℃; for 16h;
DOI:10.1055/s-0032-1317379

Reference yield:

: 536-38-9
4-chlorobenzoylmethyl bromide

: 1417910-38-3
3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / ethanol / 5 h / Reflux

2: trichlorophosphate / 1.5 h / 0 - 80 °C

3: sodium tetrahydroborate; methanol / 1 h / 20 °C

4: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 14 h / 20 °C

6: copper(l) iodide / water / 16 h / 20 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; sodium azide; sodium hydrogencarbonate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1317379

Reference yield:

: 38922-74-6
2-(4-chlorophenyl)imidazolo[1,2-a]pyridine

: 1417910-38-3
3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 1.5 h / 0 - 80 °C

2: sodium tetrahydroborate; methanol / 1 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 14 h / 20 °C

5: copper(l) iodide / water / 16 h / 20 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; sodium azide; triethylamine; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1317379