1-Cyclopropyl-7-(3-dimethylaminomethyl-3-phenyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

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Chemical Name:1-Cyclopropyl-7-(3-dimethylaminomethyl-3-phenyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
CAS No.:124563-04-8
Molecular Formula:C₂₆H₂₇F₂N₃O₃
Molecular Weight:467.515
Hs Code.:

Synonyms:1-Cyclopropyl-7-(3-dimethylaminomethyl-3-phenyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

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Chemical Property of 1-Cyclopropyl-7-(3-dimethylaminomethyl-3-phenyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

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Technology Process of 1-Cyclopropyl-7-(3-dimethylaminomethyl-3-phenyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

There total 4 articles about 1-Cyclopropyl-7-(3-dimethylaminomethyl-3-phenyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 124563-01-5
Dimethyl-(3-phenyl-pyrrolidin-3-ylmethyl)-amine

: 94695-52-0
1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

: 124563-04-8
1-Cyclopropyl-7-(3-dimethylaminomethyl-3-phenyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: With triethylamine; In acetonitrile; 1.) reflux, 3 h, 2.) room temp., 18 h;
DOI:10.1021/jm00164a060

Reference yield:

: 124562-89-6
3-phenyl-1-(phenylmethyl)-3-pyrrolidinecarboxylic acid methyl ester

: 124563-04-8
1-Cyclopropyl-7-(3-dimethylaminomethyl-3-phenyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / 6 M HCl / methanol / 1.) reflux, 3 h, 2.) room temp., 18 h

2: Et₃N / acetonitrile / 1.5 h / 60 °C

3: tetrahydrofuran / Ambient temperature

4: LiAlH₄ / tetrahydrofuran / 1.) room temp., overnight, 2.) reflux, 2 h

5: H₂ / 20percent Pd/C / methanol / 24 h / 25 °C / 2585.7 Torr

6: 58 percent / Et₃N / acetonitrile / 1.) reflux, 3 h, 2.) room temp., 18 h

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm00164a060

Reference yield:

: 124562-95-4
1-Benzyl-3-phenyl-pyrrolidine-3-carboxylic acid dimethylamide

: 124563-04-8
1-Cyclopropyl-7-(3-dimethylaminomethyl-3-phenyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran / 1.) room temp., overnight, 2.) reflux, 2 h

2: H₂ / 20percent Pd/C / methanol / 24 h / 25 °C / 2585.7 Torr

3: 58 percent / Et₃N / acetonitrile / 1.) reflux, 3 h, 2.) room temp., 18 h

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm00164a060