1-<6-azido-5-(S)-<<(tert-butyloxy)carbonyl>amino>hexyl>-3-o-tolylura

Base Information

Chemical Name:1-<6-azido-5-(S)-<<(tert-butyloxy)carbonyl>amino>hexyl>-3-o-tolylura
CAS No.:166446-74-8
Molecular Formula:C₁₉H₃₀N₆O₃
Molecular Weight:390.486
Hs Code.:

Synonyms:1-<6-azido-5-(S)-<<(tert-butyloxy)carbonyl>amino>hexyl>-3-o-tolylura

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Chemical Property of 1-<6-azido-5-(S)-<<(tert-butyloxy)carbonyl>amino>hexyl>-3-o-tolylura

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Technology Process of 1-<6-azido-5-(S)-<<(tert-butyloxy)carbonyl>amino>hexyl>-3-o-tolylura

There total 5 articles about 1-<6-azido-5-(S)-<<(tert-butyloxy)carbonyl>amino>hexyl>-3-o-tolylura which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: methanesulfonic acid 2-(S)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl ester

: 166446-74-8
1-<6-azido-5-(S)-<<(tert-butyloxy)carbonyl>amino>hexyl>-3-o-tolylura

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;
DOI:10.1021/jm00017a022

Reference yield:

: 13734-28-6
Boc-Lys-OH

: 166446-74-8
1-<6-azido-5-(S)-<<(tert-butyloxy)carbonyl>amino>hexyl>-3-o-tolylura

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / 1 N aq. NaOH / 15 h

2: 1.) isobutyl chloroformate, diisopropylethylamine, 2.) lithium aluminum hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, Et₂O, RT, 24 h

3: 46 percent / DMAP, triethylamine / CH₂Cl₂ / 2.25 h / Ambient temperature

4: 69 percent / sodium azide / dimethylformamide / 1.5 h / 80 °C

With dmap; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00017a022

Reference yield:

: 614-68-6
2-tolyl isocyanate

: 166446-74-8
1-<6-azido-5-(S)-<<(tert-butyloxy)carbonyl>amino>hexyl>-3-o-tolylura

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / 1 N aq. NaOH / 15 h

2: 1.) isobutyl chloroformate, diisopropylethylamine, 2.) lithium aluminum hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, Et₂O, RT, 24 h

3: 46 percent / DMAP, triethylamine / CH₂Cl₂ / 2.25 h / Ambient temperature

4: 69 percent / sodium azide / dimethylformamide / 1.5 h / 80 °C

With dmap; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00017a022