(2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine

Base Information

Chemical Name:(2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine
CAS No.:115074-90-3
Molecular Formula:C₅₉H₈₉NO₆Si
Molecular Weight:936.444
Hs Code.:

Synonyms:(2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine

Suppliers and Price of (2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine

There total 13 articles about (2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 262592-99-4
(2S,3R,4E,8Z,2'R)-2-(2'-acetoxyhexadecanoyl)amino-1-O-benzoyl-4,8-octadiene-1,3-diol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 115074-90-3
(2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 70 ℃; for 5h;

Reference yield:

: 693-58-3
1-Bromononane

: 115074-90-3
(2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) n-BuLi / 1.) n-hexane, THF, 1 h, -10 deg C, 2.) n-hexane, THF, HMPT, 11 h, room temperature

2: p-toluenesulfonic acid monohydrate / methanol / 18 h / Ambient temperature

3: 83 percent / H₂, quinoline / 5percent Pd/BaSO₄ / methanol / 760 Torr / Ambient temperature

4: pyridine / 9 h / 0 °C

5: dimethylsulfoxide / 18 h / Ambient temperature

6: 1.) (i-Bu)2AlH, 2.) tartaric acid / 1.) n-hexane, ether, 1 h, -20 deg C; 1 h, RT, 2.) n-hexane, ether, water, 1 h

7: 1.) triphenylphosphine / 1.) CH₂Cl₂, 0 deg C, 2.) CH₂Cl₂, 15 min, 0 deg C

8: 70 percent / n-BuLi / hexane; tetrahydrofuran / 1.) 30 min, -70 deg C, 2.) 1 h, room temperature

9: 1.) (i-Bu)2AlH / 1.) n-hexane, 3 h, 50 deg C, 2.) n-hexane, ether, toluene, 1,5 h, room temperature

10: 2 N HCl / H₂O; tetrahydrofuran / 21 h / Ambient temperature

11: pyridine / 19 h / 50 °C

12: 96 percent / imidazole / dimethylformamide / 5 h / 70 °C

With 1H-imidazole; quinoline; hydrogenchloride; n-butyllithium; hydrogen; diisobutylaluminium hydride; toluene-4-sulfonic acid; tartaric acid; triphenylphosphine; Pd-BaSO₄; In tetrahydrofuran; pyridine; methanol; hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 54373-82-9
tridec-3-yn-1-ol

: 115074-90-3
(2S,3R,4E,8Z,2'R)-N-(2'-Acetoxyhexadecanoyl)-1-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-4,8-sphingadienine

Guidance literature:: Multi-step reaction with 10 steps

1: 83 percent / H₂, quinoline / 5percent Pd/BaSO₄ / methanol / 760 Torr / Ambient temperature

2: pyridine / 9 h / 0 °C

3: dimethylsulfoxide / 18 h / Ambient temperature

4: 1.) (i-Bu)2AlH, 2.) tartaric acid / 1.) n-hexane, ether, 1 h, -20 deg C; 1 h, RT, 2.) n-hexane, ether, water, 1 h

5: 1.) triphenylphosphine / 1.) CH₂Cl₂, 0 deg C, 2.) CH₂Cl₂, 15 min, 0 deg C

6: 70 percent / n-BuLi / hexane; tetrahydrofuran / 1.) 30 min, -70 deg C, 2.) 1 h, room temperature

7: 1.) (i-Bu)2AlH / 1.) n-hexane, 3 h, 50 deg C, 2.) n-hexane, ether, toluene, 1,5 h, room temperature

8: 2 N HCl / H₂O; tetrahydrofuran / 21 h / Ambient temperature

9: pyridine / 19 h / 50 °C

10: 96 percent / imidazole / dimethylformamide / 5 h / 70 °C

With 1H-imidazole; quinoline; hydrogenchloride; n-butyllithium; hydrogen; diisobutylaluminium hydride; tartaric acid; triphenylphosphine; Pd-BaSO₄; In tetrahydrofuran; pyridine; methanol; hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;