N-(((2S,5S)-5-benzyl-4-(methylsulfonyl)morpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(((2S,5S)-5-benzyl-4-(methylsulfonyl)morpholin-2-yl)methyl)-4-methylbenzenesulfonamide
CAS No.:1393751-26-2
Molecular Formula:C₂₀H₂₆N₂O₅S₂
Molecular Weight:438.569
Hs Code.:

Synonyms:N-(((2S,5S)-5-benzyl-4-(methylsulfonyl)morpholin-2-yl)methyl)-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(((2S,5S)-5-benzyl-4-(methylsulfonyl)morpholin-2-yl)methyl)-4-methylbenzenesulfonamide

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Technology Process of N-(((2S,5S)-5-benzyl-4-(methylsulfonyl)morpholin-2-yl)methyl)-4-methylbenzenesulfonamide

There total 4 articles about N-(((2S,5S)-5-benzyl-4-(methylsulfonyl)morpholin-2-yl)methyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1393751-16-0
(S)-N-allyl-N-(1-hydroxy-3-phenylpropan-2-yl)methanesulfonamide

: 70-55-3
toluene-4-sulfonamide

: 1393751-26-2
N-(((2S,5S)-5-benzyl-4-(methylsulfonyl)morpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: With copper(II) 2-ethylhexanoate; caesium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; for 24h; diastereoselective reaction;
DOI:10.1021/ol301984b

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1393751-26-2
N-(((2S,5S)-5-benzyl-4-(methylsulfonyl)morpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; N-ethyl-N,N-diisopropylamine / acetone; water / 16 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

3.2: 16 h / 20 °C

4.1: copper(II) 2-ethylhexanoate; caesium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 130 °C

With lithium aluminium tetrahydride; copper(II) 2-ethylhexanoate; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol301984b

Reference yield:

: 42361-65-9
N-(methylsulfonyl)-L-phenylalanine

: 1393751-26-2
N-(((2S,5S)-5-benzyl-4-(methylsulfonyl)morpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 16 h / 20 °C

3.1: copper(II) 2-ethylhexanoate; caesium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 130 °C

With lithium aluminium tetrahydride; copper(II) 2-ethylhexanoate; sodium hydride; caesium carbonate; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1021/ol301984b