N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide

Base Information

• Chemical Name: N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide
• CAS No.: 260444-04-0
• Molecular Formula: C₁₄H₉BrF₂N₂O₂S
• Molecular Weight: 387.204
• Mol file: 260444-04-0.mol

Synonyms:N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide

Chemical Property of N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide

There total 3 articles about N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-benzamide (343975-62-2) → N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide (260444-04-0)

Guidance literature:

With Lawessons reagent; N,N,N,N,N,N-hexamethylphosphoric triamide; at 100 ℃; for 15h;

DOI:10.1021/jm001104n

Reference yield:

2-bromo-4,5-difluoro-aniline (64695-79-0) → N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide (260444-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / pyridine / 1 h / Heating

2: 86 percent / Lawesson's reagent; HMPA / 15 h / 100 °C

With Lawessons reagent; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1021/jm001104n

Reference yield:

3-methyl-4-nitro-benzoyl chloride (35675-46-8) → N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide (260444-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / pyridine / 1 h / Heating

2: 86 percent / Lawesson's reagent; HMPA / 15 h / 100 °C

With Lawessons reagent; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1021/jm001104n

upstream raw materials:

N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-benzamide

2-bromo-4,5-difluoro-aniline

3-methyl-4-nitro-benzoyl chloride

Downstream raw materials:

5,6-difluoro-2-(4-amino-3-methylphenyl)benzothiazole