N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine

Base Information

Chemical Name:N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine
CAS No.:1259017-71-4
Molecular Formula:C₂₄H₂₀Cl₂FN₃O₂
Molecular Weight:472.346
Hs Code.:

Synonyms:N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine

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Chemical Property of N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine

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Technology Process of N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine

There total 7 articles about N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 109-70-6
1.3-chlorobromopropane

: 230955-55-2
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-ol

: 1259017-71-4
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine

Guidance literature:: 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-ol; With tetrabutylammomium bromide; potassium carbonate; In acetonitrile; for 0.333333h; Reflux;

1.3-chlorobromopropane; In acetonitrile; for 2h; Reflux;
DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

: 394-31-0
2-amino-5-hydroxybenzoic acid

: 1259017-71-4
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 0.5 h / 150 °C

2.1: pyridine / 2 h / Reflux

3.1: thionyl chloride; N,N-dimethyl-formamide / 6 h / Reflux

4.1: triethylamine / isopropyl alcohol / 4 h / Reflux

5.1: ammonia; water / methanol / 3 h / 20 °C

6.1: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 0.33 h / Reflux

6.2: 2 h / Reflux

With pyridine; thionyl chloride; tetrabutylammomium bromide; ammonia; water; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In methanol; isopropyl alcohol; acetonitrile; 1.1: Neimentowaki synthesis;
DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

: 179246-11-8
4-chloroquinazoline-6-yl acetate

: 1259017-71-4
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / isopropyl alcohol / 4 h / Reflux

2.1: ammonia; water / methanol / 3 h / 20 °C

3.1: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 0.33 h / Reflux

3.2: 2 h / Reflux

With tetrabutylammomium bromide; ammonia; water; potassium carbonate; triethylamine; In methanol; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmcl.2011.04.096