2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile

Base Information

Chemical Name:2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile
CAS No.:265106-96-5
Molecular Formula:C₁₉H₁₆BrN₅OS
Molecular Weight:442.339
Hs Code.:

Synonyms:2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile

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Chemical Property of 2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile

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Technology Process of 2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile

There total 2 articles about 2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 2972-74-9
2-(3-bromobenzylidene)malononitrile

: 84839-77-0
1-[2-(4-morpholinyl)-1,3-thiazol-5-yl]ethanone

: 265106-96-5
2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile

Guidance literature:: With ammonium acetate; In 1,2-dichloro-ethane; Heating;
DOI:10.1016/j.bmc.2005.03.023

Reference yield:

: 21429-06-1
2-(morpholine-1-yl)thiazole

: 265106-96-5
2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 41 percent / tetrahydrofuran; hexane / 1 h / -60 °C

2.1: 45 percent / ammonium acetate / 1,2-dichloro-ethane / Heating

With ammonium acetate; n-butyllithium; In tetrahydrofuran; hexane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2005.03.023

Reference yield: 73.0%

: 265106-96-5
2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile

: 122-51-0
orthoformic acid triethyl ester

: 856014-18-1
N-[4-(3-bromophenyl)-3-cyano-6-(2-morpholin-4-yl-1,3-thiazol-5-yl)pyridin-2-yl]formamidine

Guidance literature:: 2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile; orthoformic acid triethyl ester; With ammonium sulfate; for 6h; Heating;

With ammonia; In ethanol; at 20 ℃;
DOI:10.1016/j.bmc.2005.03.023