2972-74-9

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 109-77-3 malononitrile 
• 67073-72-7 3-bromobenzaldehyde dimethyl acetal 
• 75148-49-1 3-bromobenzaldehyde diethylacetal 

Downstream Products

• 94833-75-7 2-Amino-4-(3-bromo-phenyl)-1,5-dithia-spiro[5.5]undec-2-ene-3-carbonitrile 
• 128462-29-3 ethyl 5-amino-7-(m-bromophenyl)-6-cyano-3,4-dihydro-4-oxo-3-phenylphthalazine-1-carboxylate 
• 122135-15-3 4-(m-bromophenyl)-5-cyano-3-methyl-p-tolylpyrazole 
• 81829-57-4 6-amino-4-(3-bromophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylic acid ethyl ester 
• 81829-59-6 2-amino-4-(3-bromophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 81829-61-0 2-amino-4-(3-bromophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 94833-78-0 4-(3-Bromo-phenyl)-2-thioxo-2,5,6,7-tetrahydro-1H-[1]pyrindine-3-carbonitrile 
• 94833-73-5 7-Amino-9-(3-bromo-phenyl)-6,10-dithia-spiro[4.5]dec-7-ene-8-carbonitrile 
• 89607-41-0 2-amino-4-(m-bromophenyl)-3-cyano-4,7-dihydro-5-methylpyrano<2,3-c>pyrazole 
• 727382-19-6 6-amino-4-(3-bromo-phenyl)-6'-pyrrolidin-1-yl-[2,3']bipyridinyl-5-carbonitrile 
• 727382-21-0 6-amino-4-(3-bromo-phenyl)-6'-thiomorpholin-4-yl-[2,3']bipyridinyl-5-carbonitrile 
• 727382-03-8 6-amino-4-(3-bromo-phenyl)-6'-(methyl-pyridin-3-ylmethyl-amino)-[2,3']bipyridinyl-5-carbonitrile 
• 727383-05-3 6''-amino-4''-(3-bromo-phenyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-[1,2';5',2'']terpyridine-5''-carbonitrile 
• 727384-31-8 6-amino-4-(3-bromo-phenyl)-6'-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-[2,3']bipyridinyl-5-carbonitrile 

Relevant academic research and scientific papers

Ultrasonic synthesis, characterization, and antibacterial evaluation of novel heterocycles containing hexahydroquinoline and pyrrole moieties

Condensation reaction of dimedone with 2-amino-1-methyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile in ethanol containing a catalytic amount of p-toluenesulfonic acid (TsOH) afforded 2-(5,5-dimethyl-3-oxocyclohex-1-enylamino)-1-methyl-4,5-diphenyl-1H-pyrrole-3

Stereoselective multicomponent synthesis of (2RS,6SR)-2,6-diaryl-3,3,5,5-tetracyanopiperidines

Multicomponent reaction between alkylidenemalononitriles, formaldehyde, and ammonium acetate upon reflux in alcohols gives stereoselectively 2,6-diaryl-3,3,5,5-tetracyanopiperidines in 65—92% yields. In this process, ammonium acetate acts as both a cataly

Introduction of succinimide as a green and sustainable organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b] pyran derivatives

Aim and Objective: In this work, we tried to introduce a non-toxic and stable organic compound named succinimide as a green and efficient organo-catalyst for the promotion of the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives

Development of an efficient, one-pot, multicomponent protocol for synthesis of 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives

A one-pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This economical protocol

Nickel?alkyne?functionalized metal?organic frameworks: An efficient and reusable catalyst

Electron-donating groups in the robust MOF motif are able to provide an excellent catalytic platform, therefore obtaining site-isolated metal sites. In this study, the terminal alkyne is firstly introduced into UiO-66-type metal-organic frameworks (UiO-66-alkyne). Herein, to further study the application potential of this material, a covalently bonded nickel catalyst based on the alkynyl-tagged UiO-66-alkyne has been prepared and afforded us unprecedented highly dispersed and highly efficient catalytic active species. Meanwhile, this nickel-contained catalyst method for joining metals provided an alternative pathway regarding catalyst designing. With UiO-66-alkyne-Ni, the heterogeneous transformation of homogeneous catalysts is realized. Using benzaldehyde and malononitrile as starting materials, we were able to catalyze the Knoevenagel condensation within 45 min under room temperature with yield (> 99 %). Moreover, the recovery rate of the UiO-66-alkyne-Ni also outperformed previous MOFs in both small-scale and gram-level reactions, which shows UiO-66-alkyne-Ni is a potential contributor to the subsequent industrialization.

Phosphine-Catalyzed (4 + 2) Annulation of δ-Sulfonamido-Substituted Enones with 1,1-Dicyanoalkenes: Synthesis of Piperidine Derivatives

The δ-sulfonamido-substituted enones were employed as phosphine acceptor in phosphine-catalyzed (4 + 2) annulation of 1,1-dicyanoalkenes. They served as a four-membered synthon to react with 1,1-dicyanoalkenes under mild reaction conditions, producing pip

Cascade reaction synthesis method of 2-(phenylmethylene)malononitrile or derivative thereof

The invention discloses a cascade reaction synthesis method of 2-(phenylmethylene)malononitrile or a derivative thereof. According to the invention, a dendritic acid-alkali catalyst based on cross-linked polystyrene is synthesized, and 2-(phenylmethylene) malononitrile or a derivative thereof is synthesized in batches by successfully applying a cascade reaction into fluid chemistry, so that the method of the invention has advantages of substantially reduced, yield increase and no separation process of a catalyst and a product compared with the traditional test tube reaction.

Highly Active Bisamino Functionalized Zr(IV)-UiO-67 Metal-Organic Framework for Cascade Catalysis

This work reports the synthesis and characterization of Zr(IV)-based UiO-67-(NH2)2 (called 1) metal-organic framework. Activated 1 (named 1') was shown to be an efficient tandem catalyst in the conversion of benzaldehydedimethyl acet

Synthesis and catalytic activities of a Zn(ii) based metallomacrocycle and a metal-organic framework towards one-pot deacetalization-Knoevenagel tandem reactions under different strategies: A comparative study

Solvothermal reactions between a pyridine based amide functionalized dicarboxylic acid, 4,4′-{(pyridine-2,6-dicarbonyl)bis(azanediyl)}dibenzoic acid (H2L), and zinc(ii) nitrate in the absence and presence of a base produced the binuclear metallomacrocyclic compound [Zn2(L)2(H2O)4]·2(H2O)·6(DMF) (1) and the metallomacrocyclic based two dimensional MOF [Zn5(L)4(OH)2(H2O)4]n·8n(DMF)·4n(H2O) (2), respectively. Compound 1 bears two tetrahedral Zn(ii) centres, whereas the 2D framework 2 includes a penta-nuclear Zn(ii) cluster as a secondary building block unit, with two of the metal cations assuming a tetrahedral type geometry and the remaining three an octahedral type geometry. The topological analyses reveal that compound 1 has a 2-connected uninodal net and framework 2 has a 2, 8-connected binodal net. These compounds heterogeneously catalyse the tandem deacetalization-Knoevenagel condensation reactions carried out under conventional heating, microwave irradiation or ultrasonic irradiation. Comparative studies show that ultrasonic irradiation (final product yield of 99percent after 2 h of reaction time) provides the most favourable method (e.g., microwave irradiation leads to a final product yield of 91percent after 3 h of reaction time). Moreover, the catalysts can be reused at least for five consecutive cycles without losing activity significantly.

Structure-induced Lewis-base Ga4B2O9 and its superior performance in Knoevenagel condensation reaction

Solid Lewis-base catalysis is important in the production of fine chemicals. A Lewis-base Ga4B2O9 was synthesized by high temperature solid state reactions. It exhibited a high yield (90 %) and a high stability in Knoevena