2972-74-9

Upstream product

• 67073-72-7 3-bromobenzaldehyde dimethyl acetal 
• 109-77-3 malononitrile 
• 75148-49-1 3-bromobenzaldehyde diethylacetal 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 94833-75-7 2-Amino-4-(3-bromo-phenyl)-1,5-dithia-spiro[5.5]undec-2-ene-3-carbonitrile 
• 128462-29-3 ethyl 5-amino-7-(m-bromophenyl)-6-cyano-3,4-dihydro-4-oxo-3-phenylphthalazine-1-carboxylate 
• 122135-15-3 4-(m-bromophenyl)-5-cyano-3-methyl-p-tolylpyrazole 
• 81829-57-4 6-amino-4-(3-bromophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylic acid ethyl ester 
• 81829-59-6 2-amino-4-(3-bromophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 81829-61-0 2-amino-4-(3-bromophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 94833-78-0 4-(3-Bromo-phenyl)-2-thioxo-2,5,6,7-tetrahydro-1H-[1]pyrindine-3-carbonitrile 
• 94833-73-5 7-Amino-9-(3-bromo-phenyl)-6,10-dithia-spiro[4.5]dec-7-ene-8-carbonitrile 
• 89607-41-0 2-amino-4-(m-bromophenyl)-3-cyano-4,7-dihydro-5-methylpyrano<2,3-c>pyrazole 
• 81829-56-3 5-Acetyl-2-amino-4-(3-bromo-phenyl)-6-methyl-4H-pyran-3-carbonitrile 
• 127118-61-0 2,6-diamino-4-(3-bromophenyl)-4H-thiopyran-3,5-dicarbonitrile 

Relevant academic research and scientific papers

Ultrasonic synthesis, characterization, and antibacterial evaluation of novel heterocycles containing hexahydroquinoline and pyrrole moieties

Condensation reaction of dimedone with 2-amino-1-methyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile in ethanol containing a catalytic amount of p-toluenesulfonic acid (TsOH) afforded 2-(5,5-dimethyl-3-oxocyclohex-1-enylamino)-1-methyl-4,5-diphenyl-1H-pyrrole-3

Stereoselective multicomponent synthesis of (2RS,6SR)-2,6-diaryl-3,3,5,5-tetracyanopiperidines

Multicomponent reaction between alkylidenemalononitriles, formaldehyde, and ammonium acetate upon reflux in alcohols gives stereoselectively 2,6-diaryl-3,3,5,5-tetracyanopiperidines in 65—92% yields. In this process, ammonium acetate acts as both a cataly

Introduction of succinimide as a green and sustainable organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b] pyran derivatives

Aim and Objective: In this work, we tried to introduce a non-toxic and stable organic compound named succinimide as a green and efficient organo-catalyst for the promotion of the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives

Development of an efficient, one-pot, multicomponent protocol for synthesis of 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives

A one-pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This economical protocol

Nickel?alkyne?functionalized metal?organic frameworks: An efficient and reusable catalyst

Electron-donating groups in the robust MOF motif are able to provide an excellent catalytic platform, therefore obtaining site-isolated metal sites. In this study, the terminal alkyne is firstly introduced into UiO-66-type metal-organic frameworks (UiO-66-alkyne). Herein, to further study the application potential of this material, a covalently bonded nickel catalyst based on the alkynyl-tagged UiO-66-alkyne has been prepared and afforded us unprecedented highly dispersed and highly efficient catalytic active species. Meanwhile, this nickel-contained catalyst method for joining metals provided an alternative pathway regarding catalyst designing. With UiO-66-alkyne-Ni, the heterogeneous transformation of homogeneous catalysts is realized. Using benzaldehyde and malononitrile as starting materials, we were able to catalyze the Knoevenagel condensation within 45 min under room temperature with yield (> 99 %). Moreover, the recovery rate of the UiO-66-alkyne-Ni also outperformed previous MOFs in both small-scale and gram-level reactions, which shows UiO-66-alkyne-Ni is a potential contributor to the subsequent industrialization.

Phosphine-Catalyzed (4 + 2) Annulation of δ-Sulfonamido-Substituted Enones with 1,1-Dicyanoalkenes: Synthesis of Piperidine Derivatives

The δ-sulfonamido-substituted enones were employed as phosphine acceptor in phosphine-catalyzed (4 + 2) annulation of 1,1-dicyanoalkenes. They served as a four-membered synthon to react with 1,1-dicyanoalkenes under mild reaction conditions, producing pip

Structure-induced Lewis-base Ga4B2O9 and its superior performance in Knoevenagel condensation reaction

Solid Lewis-base catalysis is important in the production of fine chemicals. A Lewis-base Ga4B2O9 was synthesized by high temperature solid state reactions. It exhibited a high yield (90 %) and a high stability in Knoevena

Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids

Ionic Liquids (ILs) self-assemble to form supramolecular polymeric clusters/aggregates. The aggregation behavior of ILs influences its activity in the organic synthesis. However, the precise role of ILs in organic reactions is still unknown. It is, therefore, important to comprehend the supramolecular polymeric aggregation behavior of ILs. We are exploring the supramolecular polymeric aggregation behavior of ILs using Electrospray Ionization Mass Spectrometry (ESI-MS). We have synthesized four hydrophilic ILs (1–4) and investigated their aggregation behavior and its impact on catalytic activity in Carbon-Carbon bond formation (Knoevenagel and Claisen-Schmidt condensation). Here, we show that the aggregation behavior of ILs depends on the type and nature of cation and anion. ESI-MS (?ve) spectra reveals two different type of aggregation i.e. [CnAn+1]? & [A2 + H+]?. We have found that catalytic activity increases with increased [CnAn+1]? supramolecular aggregation. Consequently, highest yield of products obtained in ILs which show decreased anion-anion aggregation [A2 + H+]? abundance in ESI-MS. We anticipate our results to be a starting point for the establishment of desired ILs for organic synthesis.

Introduction of a new bis-derivative of succinimide (Bis-Su) as a sustainable and efficient basic organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives under green conditions

Organo-catalysts have been under great consideration for many years because of their performance and selectivity in the reactions. In this work, a new bis-succinimide (Bis-Su) compound is prepared, identified and used as a green and efficient basic organo

Reaction kinetics investigation of Malononitrile with substituted benzaldehydes in aqueous solutions of ethaline as deep eutectic solvent

Due to increasing demands for ecofriendly processes within the framework of green chemistry, and having shown substantial properties, especially in terms of toxicity, biodegradability, cost, and ease of preparation under ambient conditions, deep eutectic