(S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Base Information

Chemical Name:(S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
CAS No.:1269440-76-7
Molecular Formula:C₂₁H₂₅ClFN₇O₂
Molecular Weight:461.927
Hs Code.:

Synonyms:(S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Suppliers and Price of (S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

There total 12 articles about (S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1244039-65-3
2-chloro-5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1269440-60-9
(S)-methyl 1-(4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

: 1269440-76-7
(S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 85 ℃; for 16h;

Reference yield:

: 89897-29-0
3-amino-1-isopropyl-1H-pyrazole-4-carbonitrile

: 1269440-76-7
(S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran; diethyl ether / 0 °C / Reflux

1.2: pH 7

2.1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0 - 20 °C

2.2: pH 9 - 10

3.1: 12 h / 155 °C

4.1: lithium hydroxide / iso-butanol / 20 h / 110 °C

5.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C

6.1: trichlorophosphate / 16 h / 110 °C

7.1: triethylamine / 1,4-dioxane; isopropyl alcohol / 48 h / 125 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 85 °C

With sodium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; potassium iodide; lithium hydroxide; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; isopropyl alcohol; toluene; acetonitrile; iso-butanol;

Reference yield:

: 97619-92-6
2-((2-benzylidene-1-isopropylhydrazinyl)methylene)malononitrile

: 1269440-76-7
(S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / ethanol; water / 0.33 h / Reflux

2.1: tetrahydrofuran; diethyl ether / 0 °C / Reflux

2.2: pH 7

3.1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0 - 20 °C

3.2: pH 9 - 10

4.1: 12 h / 155 °C

5.1: lithium hydroxide / iso-butanol / 20 h / 110 °C

6.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C

7.1: trichlorophosphate / 16 h / 110 °C

8.1: triethylamine / 1,4-dioxane; isopropyl alcohol / 48 h / 125 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 85 °C

With hydrogenchloride; sodium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; potassium iodide; lithium hydroxide; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; isopropyl alcohol; toluene; acetonitrile; iso-butanol;