N-(2,4-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(2,4-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide
CAS No.:1269440-24-5
Molecular Formula:C₂₂H₂₇ClFN₇O₄S
Molecular Weight:540.018
Hs Code.:

Synonyms:N-(2,4-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide

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Chemical Property of N-(2,4-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide

Chemical Property:

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Technology Process of N-(2,4-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide

There total 13 articles about N-(2,4-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269440-76-7
(S)-methyl 1-(4-(3-(3-amino-2-chloro-5-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

: 124-63-0
methanesulfonyl chloride

: 1269440-24-5
N-(2,4-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide

Guidance literature:: With pyridine; triethylamine; at 20 ℃; for 16h;

Reference yield:

: 97619-92-6
2-((2-benzylidene-1-isopropylhydrazinyl)methylene)malononitrile

: 1269440-24-5
N-(2,4-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / ethanol; water / 0.33 h / Reflux

2.1: tetrahydrofuran; diethyl ether / 0 °C / Reflux

2.2: pH 7

3.1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0 - 20 °C

3.2: pH 9 - 10

4.1: 12 h / 155 °C

5.1: lithium hydroxide / iso-butanol / 20 h / 110 °C

6.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C

7.1: trichlorophosphate / 16 h / 110 °C

8.1: triethylamine / 1,4-dioxane; isopropyl alcohol / 48 h / 125 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 85 °C

10.1: pyridine; triethylamine / 16 h / 20 °C

With pyridine; hydrogenchloride; sodium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; potassium iodide; lithium hydroxide; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; isopropyl alcohol; toluene; acetonitrile; iso-butanol;

Reference yield:

: 1269440-49-4
1-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)ethanone

: 1269440-24-5
N-(2,4-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: tert-Butoxybis(dimethylamino)methane / 114 - 120 °C / Inert atmosphere

2: lithium hydroxide / iso-butanol / 20 h / 110 °C

3: trifluoroacetic acid; sodium nitrite / 0 - 20 °C

4: trichlorophosphate / 16 h / 110 °C

5: triethylamine / 1,4-dioxane; isopropyl alcohol / 48 h / 125 °C

6: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 85 °C

7: pyridine; triethylamine / 16 h / 20 °C

With pyridine; tert-Butoxybis(dimethylamino)methane; sodium carbonate; triethylamine; trifluoroacetic acid; lithium hydroxide; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; isopropyl alcohol; toluene; iso-butanol;