C₆₆H₁₀₇N₅O₁₆Si

Base Information

Chemical Name:C₆₆H₁₀₇N₅O₁₆Si
CAS No.:383910-60-9
Molecular Formula:C₆₆H₁₀₇N₅O₁₆Si
Molecular Weight:1254.68
Hs Code.:

C<sub>66</sub>H<sub>107</sub>N<sub>5</sub>O<sub>16</sub>Si

Synonyms:C₆₆H₁₀₇N₅O₁₆Si

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Chemical Property of C₆₆H₁₀₇N₅O₁₆Si

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Technology Process of C₆₆H₁₀₇N₅O₁₆Si

There total 9 articles about C₆₆H₁₀₇N₅O₁₆Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 383910-59-6
C₇₁H₁₁₉O₁₅N₅Si₂CH₂O

: 383910-60-9
C₆₆H₁₀₇N₅O₁₆Si

Guidance literature:: With acetic acid; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/jo0105991

Reference yield:

: 126587-71-1
Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester

: 383910-60-9
C₆₆H₁₀₇N₅O₁₆Si

Guidance literature:: Multi-step reaction with 6 steps

1.1: 78 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1.5 h / 0 °C

2.1: H₂ / Pd/C / methanol; ethyl acetate / 5 h / 2585.81 Torr

3.1: BOP-Cl; NMM / CH₂Cl₂ / 0.75 h / -15 - 0 °C

3.2: 2.90 g / NMM / CH₂Cl₂ / 6 h / 0 °C

4.1: MgBr₂ / CH₂Cl₂ / 3 h / 0 °C

5.1: 63 percent / HATU; DIEA / CH₂Cl₂ / 14 h / 0 - 20 °C

6.1: 75 percent / aq. AcOH / tetrahydrofuran / 24 h / 20 °C

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo0105991

Reference yield:

: 383910-54-1
N-Cbz-L-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylic acid

: 383910-60-9
C₆₆H₁₀₇N₅O₁₆Si

Guidance literature:: Multi-step reaction with 6 steps

1.1: 78 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1.5 h / 0 °C

2.1: H₂ / Pd/C / methanol; ethyl acetate / 5 h / 2585.81 Torr

3.1: BOP-Cl; NMM / CH₂Cl₂ / 0.75 h / -15 - 0 °C

3.2: 2.90 g / NMM / CH₂Cl₂ / 6 h / 0 °C

4.1: MgBr₂ / CH₂Cl₂ / 3 h / 0 °C

5.1: 63 percent / HATU; DIEA / CH₂Cl₂ / 14 h / 0 - 20 °C

6.1: 75 percent / aq. AcOH / tetrahydrofuran / 24 h / 20 °C

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo0105991