1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylic acid

Base Information

Chemical Name:1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylic acid
CAS No.:1334606-92-6
Molecular Formula:C₂₉H₃₂F₃N₃O₃
Molecular Weight:527.587
Hs Code.:

Synonyms:1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylic acid

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Chemical Property of 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylic acid

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Technology Process of 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylic acid

There total 8 articles about 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334607-99-6
ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate

: 1334606-92-6
1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylic acid

Guidance literature:: With water; sodium hydroxide; In isopropyl alcohol; at 20 ℃; for 3h;

Reference yield:

: 393-37-3
5-bromo-2-fluorobenzotrifluoride

: 1334606-92-6
1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

1.2: 50 °C

2.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

2.2: -60 - 20 °C

2.3: 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

4.1: acetic acid / ethanol / 1 h / 20 °C

4.2: 20 °C

4.3: 0.08 h

5.1: sodium hydroxide; water / isopropyl alcohol / 3 h / 20 °C

With potassium phosphate; n-butyllithium; potassium tert-butylate; water; acetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 2357-47-3
4-Fluoro-3-trifluoromethylaniline

: 1334606-92-6
1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice; Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

2.2: 50 °C

3.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

3.2: -60 - 20 °C

3.3: 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

5.1: acetic acid / ethanol / 1 h / 20 °C

5.2: 20 °C

5.3: 0.08 h

6.1: sodium hydroxide; water / isopropyl alcohol / 3 h / 20 °C

With potassium phosphate; n-butyllithium; tert.-butylnitrite; potassium tert-butylate; water; acetic acid; sodium hydroxide; copper(ll) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;