ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate

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Chemical Name:ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate
CAS No.:1334607-99-6
Molecular Formula:C₃₁H₃₆F₃N₃O₃
Molecular Weight:555.64
Hs Code.:

Synonyms:ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate

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Chemical Property of ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate

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Technology Process of ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate

There total 7 articles about ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1334607-97-4
2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}benzaldehyde

: 1334607-99-6
ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate

Guidance literature:: 4-carbethoxypiperidine; 2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}benzaldehyde; With acetic acid; In ethanol; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; for 0.0833333h;

Reference yield:

: 393-37-3
5-bromo-2-fluorobenzotrifluoride

: 1334607-99-6
ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

1.2: 50 °C

2.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

2.2: -60 - 20 °C

2.3: 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

4.1: acetic acid / ethanol / 1 h / 20 °C

4.2: 20 °C

4.3: 0.08 h

With potassium phosphate; n-butyllithium; potassium tert-butylate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 2357-47-3
4-Fluoro-3-trifluoromethylaniline

: 1334607-99-6
ethyl 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-4-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice; Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

2.2: 50 °C

3.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

3.2: -60 - 20 °C

3.3: 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

5.1: acetic acid / ethanol / 1 h / 20 °C

5.2: 20 °C

5.3: 0.08 h

With potassium phosphate; n-butyllithium; tert.-butylnitrite; potassium tert-butylate; acetic acid; copper(ll) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;