2-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-4-fluorobenzenesulfonyl chloride

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Chemical Name:2-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-4-fluorobenzenesulfonyl chloride
CAS No.:1609201-64-0
Molecular Formula:C₁₆H₁₉ClF₄N₂O₃S
Molecular Weight:430.851
Hs Code.:

Synonyms:2-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-4-fluorobenzenesulfonyl chloride

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Chemical Property of 2-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-4-fluorobenzenesulfonyl chloride

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Technology Process of 2-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-4-fluorobenzenesulfonyl chloride

There total 3 articles about 2-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-4-fluorobenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609201-66-2
((R)-1-ethylpyrrolidin-3-yl)-[2-(3-fluorophenyl)ethyl]amine

: 1609201-64-0
2-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-4-fluorobenzenesulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2.5 h / 20 °C / Cooling with ice

2: chlorosulfonic acid / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With chlorosulfonic acid; triethylamine; In dichloromethane;

Reference yield:

: 174257-30-8
2-(3-fluorophenyl)ethanol methanesulfonate (ester)

: 1609201-64-0
2-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-4-fluorobenzenesulfonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 80 °C / Sealed tube

2: triethylamine / dichloromethane / 2.5 h / 20 °C / Cooling with ice

3: chlorosulfonic acid / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With chlorosulfonic acid; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

Reference yield:

: 52059-53-7
2-(3-fluorophenyl)ethanol

: 1609201-64-0
2-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-4-fluorobenzenesulfonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 80 °C / Sealed tube

3: triethylamine / dichloromethane / 2.5 h / 20 °C / Cooling with ice

4: chlorosulfonic acid / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With chlorosulfonic acid; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;