(1aR,7bS)-5-{2-[2-((R)-1-ethylpyrrolidin-3-ylamino)ethyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid formic acid

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Chemical Name:(1aR,7bS)-5-{2-[2-((R)-1-ethylpyrrolidin-3-ylamino)ethyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid formic acid
CAS No.:1609200-93-2
Molecular Formula:CH₂O₂*C₂₅H₃₀FN₃O₅S
Molecular Weight:549.62
Hs Code.:

(1aR,7bS)-5-{2-[2-((R)-1-ethylpyrrolidin-3-ylamino)ethyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid formic acid

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Chemical Property of (1aR,7bS)-5-{2-[2-((R)-1-ethylpyrrolidin-3-ylamino)ethyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid formic acid

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Technology Process of (1aR,7bS)-5-{2-[2-((R)-1-ethylpyrrolidin-3-ylamino)ethyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid formic acid

There total 12 articles about (1aR,7bS)-5-{2-[2-((R)-1-ethylpyrrolidin-3-ylamino)ethyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid formic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609201-65-1
1-{2-[N-((R)-1-ethylpyrrolidin-3-yl)-N-trifluoroacetylamino]ethyl}-3-fluorobenzene

: 1609200-93-2
(1aR,7bS)-5-{2-[2-((R)-1-ethylpyrrolidin-3-ylamino)ethyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid formic acid

Guidance literature:: Multi-step reaction with 3 steps

1: chlorosulfonic acid / dichloromethane / 0.5 h / 20 °C / Cooling with ice

2: pyridine / dichloromethane / 3.5 h / 0 - 20 °C

3: lithium hydroxide; water / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

With pyridine; chlorosulfonic acid; water; lithium hydroxide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1609201-66-2
((R)-1-ethylpyrrolidin-3-yl)-[2-(3-fluorophenyl)ethyl]amine

: 1609200-93-2
(1aR,7bS)-5-{2-[2-((R)-1-ethylpyrrolidin-3-ylamino)ethyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid formic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2.5 h / 20 °C / Cooling with ice

2: chlorosulfonic acid / dichloromethane / 0.5 h / 20 °C / Cooling with ice

3: pyridine / dichloromethane / 3.5 h / 0 - 20 °C

4: lithium hydroxide; water / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

With pyridine; chlorosulfonic acid; water; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 174257-30-8
2-(3-fluorophenyl)ethanol methanesulfonate (ester)

: 1609200-93-2
(1aR,7bS)-5-{2-[2-((R)-1-ethylpyrrolidin-3-ylamino)ethyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid formic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 80 °C / Sealed tube

2: triethylamine / dichloromethane / 2.5 h / 20 °C / Cooling with ice

3: chlorosulfonic acid / dichloromethane / 0.5 h / 20 °C / Cooling with ice

4: pyridine / dichloromethane / 3.5 h / 0 - 20 °C

5: lithium hydroxide; water / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

With pyridine; chlorosulfonic acid; water; potassium carbonate; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane; acetonitrile;