2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one

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Chemical Name:2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one
CAS No.:1293915-64-6
Molecular Formula:C₂₁H₁₄BrClIN₇O
Molecular Weight:622.65
Hs Code.:

Synonyms:2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one

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Chemical Property of 2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one

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Technology Process of 2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one

There total 3 articles about 2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1293915-61-3
5-bromo-3-(2-chlorobenzyl)-2-(chloromethyl)quinazolin-4(3H)-one

: 151266-23-8
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

: 1293915-64-6
2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Darkness;

Reference yield:

: 2-bromo-6-[(chloroacetyl)amino]benzoic acid

: 1293915-64-6
2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; phosphorus trichloride / toluene / 25 h / 20 - 110 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Darkness

With potassium carbonate; triethylamine; phosphorus trichloride; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 20776-48-1
2-amino-6-chlorobenzoic acid

: 1293915-64-6
2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / toluene / 0 - 115 °C

2: triethylamine; phosphorus trichloride / toluene / 25 h / 20 - 110 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Darkness

With pyridine; potassium carbonate; triethylamine; phosphorus trichloride; In N,N-dimethyl-formamide; toluene;