2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-5-((triisopropylsilyl)ethynyl)quinazolin-4(3H)one

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Chemical Name:2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-5-((triisopropylsilyl)ethynyl)quinazolin-4(3H)one
CAS No.:1293915-99-7
Molecular Formula:C₃₈H₄₀ClN₇O₂Si
Molecular Weight:690.32
Hs Code.:

Synonyms:2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-5-((triisopropylsilyl)ethynyl)quinazolin-4(3H)one

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Chemical Property of 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-5-((triisopropylsilyl)ethynyl)quinazolin-4(3H)one

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Technology Process of 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-5-((triisopropylsilyl)ethynyl)quinazolin-4(3H)one

There total 5 articles about 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-5-((triisopropylsilyl)ethynyl)quinazolin-4(3H)one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1293915-64-6
2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-bromo-3-(2-chloro benzyl)quinazolin-4(3H)-one

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1293915-99-7
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-5-((triisopropylsilyl)ethynyl)quinazolin-4(3H)one

Guidance literature:: With diethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; Inert atmosphere; Sealed vessel; Microwave irradiation;

Reference yield:

: 2-bromo-6-[(chloroacetyl)amino]benzoic acid

: 1293915-99-7
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-5-((triisopropylsilyl)ethynyl)quinazolin-4(3H)one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; phosphorus trichloride / toluene / 25 h / 20 - 110 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Darkness

3: diethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Sealed vessel; Microwave irradiation

With potassium carbonate; diethylamine; triethylamine; phosphorus trichloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 151266-23-8
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

: 1293915-99-7
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-5-((triisopropylsilyl)ethynyl)quinazolin-4(3H)one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Darkness

2: diethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Sealed vessel; Microwave irradiation

With potassium carbonate; diethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide;