Benzene, 2-(broMoMethyl)-1-fluoro-4-Methoxy-

Base Information

• Chemical Name: Benzene, 2-(broMoMethyl)-1-fluoro-4-Methoxy-
• CAS No.: 91319-42-5
• Molecular Formula: C₈H₈BrFO
• Molecular Weight: 219.053
• Hs Code.: 2909309090
• Mol file: 91319-42-5.mol

Synonyms:2-(bromomethyl)-1-fluoro-4-methoxybenzene

Chemical Property of Benzene, 2-(broMoMethyl)-1-fluoro-4-Methoxy-

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Bromomethyl)-1-fluoro-4-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 2-(broMoMethyl)-1-fluoro-4-Methoxy-

There total 7 articles about Benzene, 2-(broMoMethyl)-1-fluoro-4-Methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2-fluoro-5-methoxyphenyl)methanol (161643-29-4) → 2-(bromomethyl)-1-fluoro-4-methoxybenzene (91319-42-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; In dichloromethane; at -5 - 20 ℃; for 4h;

DOI:10.1021/acs.jmedchem.6b01473

Reference yield: 71.0%

4-fluoro-3-methylanisol (2338-54-7) → 2-(bromomethyl)-1-fluoro-4-methoxybenzene (91319-42-5)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 4h; Heating;

DOI:10.1021/ja00236a008

Reference yield:

2-methyl-4-methoxyaniline (102-50-1) → 2-(bromomethyl)-1-fluoro-4-methoxybenzene (91319-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaNO₂, 3M HCl, 2) NH₄PF₆ / 1) 0 to 5 deg C, 3) heating with Bunsen burner to white fumes

2: 71 percent / NBS / CCl₄ / 4 h / Heating

With hydrogenchloride; N-Bromosuccinimide; ammonium hexafluorophosphate; sodium nitrite; In tetrachloromethane;

DOI:10.1021/ja00236a008

upstream raw materials:

4-fluoro-3-methylanisol

(2-fluoro-5-methoxyphenyl)methanol

2-fluoro-5-methoxybenzaldehyde

2-methyl-4-methoxyaniline

Downstream raw materials:

2-fluoro-5-methoxybenzaldehyde

(2S,5S)-2-tert-Butyl-5-(2-fluoro-5-methoxy-benzyl)-3,5-dimethyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

2-(2-fluoro-5-methoxyphenyl)acetonitrile

7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

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