5-Methoxy-2-fluorobenzyl cyanide

Base Information

• Chemical Name: 5-Methoxy-2-fluorobenzyl cyanide
• CAS No.: 672931-28-1
• Molecular Formula: C9H8FNO
• Molecular Weight: 165.167
• Hs Code.: 2909309090
• Mol file: 672931-28-1.mol

Synonyms:(2-Fluoro-5-methoxyphenyl)acetonitrile;

Chemical Property of 5-Methoxy-2-fluorobenzyl cyanide

Chemical Property:

• Vapor Pressure: 0.00421mmHg at 25°C
• Refractive Index: 1.501
• Boiling Point: 278.7 °C at 760 mmHg
• Flash Point: 122.3 °C
• Density: 1.148 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Methoxy-2-fluorobenzylcyanide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Methoxy-2-fluorobenzyl cyanide

There total 6 articles about 5-Methoxy-2-fluorobenzyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

sodium cyanide (773837-37-9) + 2-(bromomethyl)-1-fluoro-4-methoxybenzene (91319-42-5) → 2-(2-fluoro-5-methoxyphenyl)acetonitrile (672931-28-1)

Guidance literature:

In ethanol; at 85 ℃; for 2h;

Reference yield:

methyl 2-fluoro-5-methoxybenzoate (96826-42-5) → 2-(2-fluoro-5-methoxyphenyl)acetonitrile (672931-28-1)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / -78 - 20 °C

2: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C

3: ethanol / 2 h / 85 °C

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

(2-fluoro-5-methoxyphenyl)methanol (161643-29-4) → 2-(2-fluoro-5-methoxyphenyl)acetonitrile (672931-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C

2: ethanol / 2 h / 85 °C

With carbon tetrabromide; triphenylphosphine; In ethanol; dichloromethane;

upstream raw materials:

sodium cyanide

2-(bromomethyl)-1-fluoro-4-methoxybenzene

2-fluoro-5-hydroxybenzoic acid

methyl 2-fluoro-5-methoxybenzoate

Downstream raw materials:

7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-one

2-(2-fluoro-5-methoxyphenyl)acetic acid

2-(2-fluoro-5-hydroxyphenyl)-3-phenylpropionitrile

Refernces

• 1、 -. "MULTIPLE KINASE PATHWAY INHIBITORS". Page/Page column 302-303. . Retrieved 2014/04/17.