ethyl (3aS,4RS,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-4-hydroxy-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

Base Information

Chemical Name:ethyl (3aS,4RS,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-4-hydroxy-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
CAS No.:1236230-80-0
Molecular Formula:C₂₆H₃₂N₂O₄S
Molecular Weight:468.617
Hs Code.:

Synonyms:ethyl (3aS,4RS,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-4-hydroxy-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

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Chemical Property of ethyl (3aS,4RS,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-4-hydroxy-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

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Technology Process of ethyl (3aS,4RS,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-4-hydroxy-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

There total 1 articles about ethyl (3aS,4RS,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-4-hydroxy-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 14660-52-7
ethyl 5-bromovalerate

: 28092-52-6
(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

: 1236230-80-0
ethyl (3aS,4RS,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-4-hydroxy-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

Guidance literature:: ethyl 5-bromovalerate; With iodine; zinc; In N,N-dimethyl-formamide; at 80 ℃; for 4.5h; Inert atmosphere;

(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione; With palladium 10% on activated carbon; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; at 30 ℃; for 30h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetasy.2010.03.041

Reference yield: 91.0%

: 1236230-80-0
ethyl (3aS,4RS,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-4-hydroxy-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

: 292151-19-0
(3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid ethyl ester

Guidance literature:: With sodium tetrahydroborate; trifluoroacetic acid; In dichloromethane; at 25 ℃; Cooling with ice; Inert atmosphere;
DOI:10.1016/j.tetasy.2010.03.041