14660-52-7Relevant articles and documents
HYDROLYSIS IN THE ABSENCE OF BULK WATER 2. CHEMOSELECTIVE HYDROLYSIS OF NITRILES USING TETRAHALOPHTHALIC ACIDS
Rounds, William D.,Eaton, Jefferson T.,Urbanowicz, John H.,Gribble, Gordon W.
, p. 6557 - 6560 (1988)
The reaction of nitriles with tetrafluorophthalic or tetrachlorophthalic acid gives carboxylic acids in good yield.The reaction is chemoselective in that the nitrile functionality can be hydrolyzed in the presence of ester groups.
Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound
Mirzoeva, Salida,Sawkar, Anu,Zasadzki, Magdalena,Guo, Ling,Velentza, Anastasia V.,Dunlap, Vincent,Bourguignonl, Jean-Jacques,Ramstrom, Helena,Haiech, Jacques,Van Eldik, Linda J.,Watterson
, p. 563 - 566 (2002)
Excessive glial activation, with overproduction of cytokines and oxidative stress products, is detrimental and a hallmark of neurodegenerative disease pathology. Suppression of glial activation is a potential therapeutic approach, and protein kinases are targets of some antiinflammatory drugs. To address an unmet need for selective inhibitors of glial activation, we developed a novel 3-amino-6-phenylpyridazine derivative that selectively blocks increased IL-1β, iNOS, and NO production by activated glia, without inhibition of potentially beneficial glial functions.
Unusual Adsorption at the Air-Water Interface of a Zwitterionic Carboxybetaine with a Large Charge Separation
Ma, Kun,Li, Pei Xun,Dong, Chu Chuan,Thomas, Robert K.,Penfold, Jeffrey
, p. 3340 - 3347 (2016/05/10)
The structures of layers of three different dodecylcarboxybetaine surfactants adsorbed at the air-water interface have been determined by neutron reflection. The zwitterionic compounds differed in the length of the spacer separating the quaternary ammonium and carboxylate groups, which was (CH2)1, (CH2)4, or (CH2)8. The limiting area per molecule was found to be 45, 52, or 84 ?2, respectively, and compared reasonably with results from surface tension showing that the Gibbs prefactor is 1 in each case. Isotopic labeling was used to distinguish between the position of the alkyl and spacer groups in the layer. The spacer was found to be well-immersed in water for the (CH2)1 and (CH2)4 spacers but significantly above water for the (CH2)8 spacer. The distribution of the (CH2)8 spacer along the surface normal was found to be similar to that of the dodecyl group; i.e., it projects out of the water, contrary to an earlier hypothesis that it forms a loop. Comparison of the overlap of water with dodecyl and spacer groups also indicates that the (CH2)8 spacer is well out of the water. This in turn suggests that the anionic carboxylic acid group, which is dissociated in solution, is not ionized in the adsorbed layer. A further observation is that the dodecylcarboxybetaine with the (CH2)8 spacer reaches surface saturation at one-tenth of the critical micelle concentration. This is highly unusual and is attributed to the long spacer destabilizing the micelle relative to the surface layer.
Synthesis of 7-triazole-substituted camptothecin via click chemistry and evaluation of in vitro antitumor activity
Wang, Lei,Yuan, Wei,Zhang, Jie,Tong, Linjiang,Luo, Yu,Chen, Yi,Lu, Wei,Huang, Qingqing
, p. 157 - 162 (2014/03/21)
Camptothecin (CPT) is a natural topoisomerase I inhibitor with powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers. To discover more potent antitumor agents, a series of new CPT derivatives were synthesized utilizing click chemistry. All compounds were assessed for cytotoxicity against A549, HCT-116, HT-29, LoVo, MDA-MB-231 cell lines, and some compounds exhibited good in vitro potency. Furthermore, all compounds kept or enhanced Topo I inhibition. A series of novel 7-triazole substituted camptothecin via click chemistry was designed, synthesized, and evaluated for their in vitro antitumor activity. Copyright
