3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde

Base Information

Chemical Name:3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde
CAS No.:1392109-84-0
Molecular Formula:C₂₉H₄₇NO₄
Molecular Weight:473.696
Hs Code.:

Synonyms:3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde

Suppliers and Price of 3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde

There total 9 articles about 3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1392109-81-7
3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-(11-hydroxyundecyl)piperidine

: 1392109-84-0
3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol301672y

Reference yield:

: 3-[(11-tert-butyldiphenylsilyloxy)undecyl]-3-(methoxycarbonyl)-2-piperidone

: 1392109-84-0
3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2: dichloromethane / 2 h / 20 °C / Inert atmosphere

3: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 20 h / Inert atmosphere; Reflux

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

5: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

With lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol301672y

Reference yield:

: 675-20-7
piperidin-2-one

: 1392109-84-0
3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

3.2: 80 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

6.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

7.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 20 h / Inert atmosphere; Reflux

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

9.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol301672y