2-bromo-N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N-(6-oxo-cyclohex-1-enyl)-benzamide

Base Information

• Chemical Name: 2-bromo-N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N-(6-oxo-cyclohex-1-enyl)-benzamide
• CAS No.: 306971-36-8
• Molecular Formula: C₂₁H₃₀BrNO₃Si
• Molecular Weight: 452.464
• Mol file: 306971-36-8.mol

Synonyms:2-bromo-N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N-(6-oxo-cyclohex-1-enyl)-benzamide

Chemical Property of 2-bromo-N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N-(6-oxo-cyclohex-1-enyl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N-(6-oxo-cyclohex-1-enyl)-benzamide

There total 1 articles about 2-bromo-N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N-(6-oxo-cyclohex-1-enyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

cyclohexane-1,2-dione (765-87-7) + 2-bromobenzoic acid chloride (7154-66-7) + 2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine (101711-55-1) → 2-bromo-N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N-(6-oxo-cyclohex-1-enyl)-benzamide (306971-36-8)

Guidance literature:

cyclohexane-1,2-dione; 2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine; In toluene; for 3h; Heating;

2-bromobenzoic acid chloride; With triethylamine; In toluene; at 20 ℃;

DOI:10.1016/S0040-4020(00)00646-3

Reference yield: 58.0%

2-bromo-N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N-(6-oxo-cyclohex-1-enyl)-benzamide (306971-36-8) → N-(2-hydroxyethyl)-N-(6-oxocyclohex-1-enyl)-2-bromobenzamide (306971-53-9)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1016/S0040-4020(00)00646-3

upstream raw materials:

cyclohexane-1,2-dione

2-bromobenzoic acid chloride

2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine

Downstream raw materials:

N-(2-hydroxyethyl)-N-(6-oxocyclohex-1-enyl)-2-bromobenzamide