1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one

Base Information

• Chemical Name: 1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one
• CAS No.: 1365536-83-9
• Molecular Formula: C₁₇H₁₈O₅
• Molecular Weight: 302.327
• Mol file: 1365536-83-9.mol

Synonyms:1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one

Chemical Property of 1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one

There total 5 articles about 1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

bromethyl methyl ether (13057-17-5) + 1‐(2‐(benzyloxy)‐4,6‐dihydroxyphenyl)ethan‐1‐one (39548-86-2) → 1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one (1365536-83-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h; regioselective reaction;

DOI:10.1016/j.tetlet.2012.01.054

Reference yield: 87.0%

2-benzyloxy-4,6-bis(methoxymethyloxy)acetophenone (115623-29-5) → 1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one (1365536-83-9)

Guidance literature:

With water; In acetone; for 5h; Reflux;

DOI:10.1016/j.tetasy.2013.02.012

Reference yield:

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone (65490-09-7) → 1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one (1365536-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C / Inert atmosphere

2: water / acetone / 5 h / Reflux

With water; potassium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.tetasy.2013.02.012

upstream raw materials:

bromethyl methyl ether

1‐(2‐(benzyloxy)‐4,6‐dihydroxyphenyl)ethan‐1‐one

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

2-benzyloxy-4,6-bis(methoxymethyloxy)acetophenone

Downstream raw materials:

(E)-1-(2-benzyloxy-6-hydroxy-4-methoxymethoxyphenyl)-3-(4-benzyloxy-3-methoxyphenyl)propenone

tricin-7-β-D-glucopyranoside

C₃₂H₃₀O₇

C₄₃H₃₈O₆