65490-09-7

Basic information

• Product Name: Ethanone, 1-[2-hydroxy-4,6-bis(methoxymethoxy)phenyl]-
• CAS NO: 65490-09-7
• Molecular Formula: C12H16O6
• Molecular Weight: 256.255
• Mol File: 65490-09-7.mol
• Article Data: 94

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2-hydroxy-4,6-bis(methoxymethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-hydroxy-4,6-bis(methoxymethoxy)phenyl]-(65490-09-7)
• EPA Substance Registry System: Ethanone, 1-[2-hydroxy-4,6-bis(methoxymethoxy)phenyl]-(65490-09-7)

Safety Data

• Hazardous Substances Data: 65490-09-7(Hazardous Substances Data)

Upstream product

• 13057-17-5 bromethyl methyl ether 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 109-87-5 Dimethoxymethane 
• 542-88-1 bis(2-chloromethyl)ether 
• 107-30-2 chloromethyl methyl ether 
• 91878-51-2 euchrestaflavanone C 
• 71386-98-6 2',4'-dihydroxy-6'-(methoxymethoxy)acetophenone 
• 108-73-6 3,5-dihydroxyphenol 

Downstream Products

• 84092-45-5 2',4'-bis(methoxymethoxy)-5'-(3,3-dimethylallyl)-6'-hydroxyacetophenone 
• 90632-20-5 1-[6-hydroxy-2,4-bis(methoxymethoxy)-3-(3-methylbut-2-en-1-yl)phenyl]ethanone 
• 36804-11-2 2,4,6-tri-MOM phloracetophenone 
• 169132-92-7 3,4-Bis(benzyloxy)-2'-hydroxy-4',6'-bis(methoxymethoxy)chalcone 
• 157027-26-4 (E)-3-[3,4-Dimethoxy-2-(3-methyl-but-2-enyl)-phenyl]-1-(2-hydroxy-4,6-bis-methoxymethoxy-phenyl)-propenone 
• 1026295-20-4 (E)-3-[3,4-Bis-methoxymethoxy-2-(3-methyl-but-2-enyl)-phenyl]-1-(2-hydroxy-4,6-bis-methoxymethoxy-phenyl)-propenone 
• 1026369-80-1 (E)-3-[3,4-Bis-methoxymethoxy-2,5-bis-(3-methyl-but-2-enyl)-phenyl]-1-(2-hydroxy-4,6-bis-methoxymethoxy-phenyl)-propenone 
• 217442-54-1 (E)-3-(2,2-dimethyl-2H-chromen-6-yl)-1-(2-hydroxy-4,6-dimethoxymethyloxyphenyl)-2-propen-1-one 
• 297132-90-2 1-(2-hydroxy-4,6-bismethoxymethoxyphenyl)-3-(3-methoxy-4,5-bis-methoxymethoxyphenyl)propenoate 
• 169132-91-6 (E)-1-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-3-phenylprop-2-en-1-one 
• 314734-03-7 2'-hydroxy-3,4,4',6'-tetrakis(methoxymethoxy)chalcone 
• 916331-01-6 trans-3-(4-allyloxyphenyl)-1-[2,4-bis(methoxymethoxy)-6-hydroxyphenyl]prop-2-en-1-one 

Relevant articles and documents

Total Synthesis of the Neuroprotective Agent Cudraisoflavone J

Cudraisoflavone J (1), isolated fromCudrania tricuspidata, is a potent neuroprotective compound with a chiral center. Herein, we report the first total synthesis of racemic cudraisoflavone J (1) using a Claisen rearrangement and a Suzuki coupling reaction as the key steps. Racemic secondary alcohol was kinetically resolved to give (+)- and (?)-cudraisoflavone J with up to 97 and 88% enantiomeric excess, respectively. The modified Mosher’s method was used to elucidate the absolute configuration of naturally occurring cudraisoflavone J.

COMPOUNDS HAVING HEPATIAL DISEASE EFFECTIVE

The invention discloses a compound with a hepatopathy curative effect, and the compound is a compound shown as a general formula (I), an optical isomer or pharmaceutically acceptable salt thereof, canbe applied to treatment or prevention of hepatopathy, particularly to drugs for treating or preventing fatty liver, liver fibrosis or liver cirrhosis, and has a good application prospect.

Anti‐melanogenic properties of velutin and its analogs?

Velutin, one of the flavones contained in natural plants, has various beneficial activities, such as skin whitening, as well as anti‐inflammatory, anti‐allergic, antioxidant, and antimicrobial activities. However, the relationship between the structure of velutin and its anti‐melanogenesis activity is not yet investigated. In this study, we obtained 12 velutin derivatives substituted at C5, C7, C3′, and C4′ of the flavone backbone with hydrogen, hydroxyl, and methoxy functionalities by chemical synthesis, to perform SAR analysis of velutin structural analogues. The SAR study revealed that the substitution of functional groups at C5, C7, C3′, and C4′ of the flavone backbone affects biological activities related to melanin synthesis. The coexistence of hydroxyl and methoxy at the C5 and C7 position is essential for inhibiting tyrosinase activity. However, 1,2‐diol compounds substituted at C3′ and C4′ of flavone backbone induce apoptosis of melanoma cells. Further, substitution at C3′ and C4′ with methoxy or hydrogen is essential for inhibiting melanogenesis. Thus, this study would be helpful for the development of natural‐derived functional materials to regulate melanin synthesis.