1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid

Base Information

• Chemical Name: 1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid
• CAS No.: 152818-34-3
• Molecular Formula: C₁₉H₁₇NO₃
• Molecular Weight: 307.349
• Mol file: 152818-34-3.mol

Synonyms:1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid

Chemical Property of 1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid

There total 3 articles about 1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzoyl-4,5-dimethylbenzoic acid (152818-36-5) + Diethyl 2-bromomalonate (685-87-0) → 6,7-dimethyl-4-phenylisocoumarin-3-carboxylic acid (≡6,7-dimethyl-1-oxo-4-phenyl-1H-2-benzopyran-3-carboxylic acid) + 1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid (152818-34-3)

Guidance literature:

With hydrogenchloride; potassium carbonate; acetic acid; In water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

2-benzoyl-4,5-dimethylbenzoic acid (152818-36-5) → 1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid (152818-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) K₂CO₃, 2.) AcOH, conc. HCl / 1.) acetone, DMF, RT, 60 h, 2.) 110 deg C, 5 h

2: 2.) 4 N HCl / 1.) MeOH, RT, 2 h, 2.) EtOAc, RT, 2 h

With hydrogenchloride; potassium carbonate; acetic acid;

DOI:10.1021/jm00016a014

Reference yield:

→ 1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid (152818-34-3)

Guidance literature:

upstream raw materials:

2-benzoyl-4,5-dimethylbenzoic acid

Diethyl 2-bromomalonate

Downstream raw materials:

1,2-Dihydro-3-hydroxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

1,2-Dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinoline acetic acid

4-(4-Fluorophenyl)-2,6,7-trimethyl-1(2H)-isoquinolinone-3-carboxylic acid

2-(3-Ethoxycarbonylpropyl)-6,7-dimethyl-4-phenyl-1 (2H)-isoquinolinone-3-carboxylic acid

Refernces

• 1、 -. "Isoquinolinyl compounds which are useful in treating cerebral vascular disorders". . . Retrieved 2008/06/13.
• 2、 Natsugari, Hideaki,Ikeura, Yoshinori,Kiyota, Yutaka,Ishichi, Yuji,Ishimaru, Takenori,et al.. "Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyridopyridine". . p. 3106 - 3120. Retrieved 2007/10/02.