2,6,7-Trimethyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride

Base Information

Chemical Name:2,6,7-Trimethyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride
CAS No.:1026233-53-3
Molecular Formula:C₁₉H₁₆ClNO₂
Molecular Weight:325.795
Hs Code.:

Synonyms:2,6,7-Trimethyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride

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Chemical Property of 2,6,7-Trimethyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride

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Technology Process of 2,6,7-Trimethyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride

There total 3 articles about 2,6,7-Trimethyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 152818-34-3
1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid

: 1026233-53-3
2,6,7-Trimethyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride

Guidance literature:: With (COCl₂)2; N,N-dimethyl-formamide; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1021/jm00016a014

Reference yield:

: 152818-36-5
2-benzoyl-4,5-dimethylbenzoic acid

: 1026233-53-3
2,6,7-Trimethyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) K₂CO₃, 2.) AcOH, conc. HCl / 1.) acetone, DMF, RT, 60 h, 2.) 110 deg C, 5 h

2: 2.) 4 N HCl / 1.) MeOH, RT, 2 h, 2.) EtOAc, RT, 2 h

3: (COCl₂)2, DMF / tetrahydrofuran / 0.5 h / Ambient temperature

With hydrogenchloride; (COCl₂)2; potassium carbonate; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1021/jm00016a014

Reference yield:

: 152818-35-4
6,7-dimethyl-1-oxo-4-phenyl-1H-2-benzopyran-3-carboxylic acid

: 1026233-53-3
2,6,7-Trimethyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) 4 N HCl / 1.) MeOH, RT, 2 h, 2.) EtOAc, RT, 2 h

2: (COCl₂)2, DMF / tetrahydrofuran / 0.5 h / Ambient temperature

With hydrogenchloride; (COCl₂)2; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1021/jm00016a014