(R)-4-Benzyl-3-{(E)-(S)-2-[(1S,2R)-1-hydroxy-2-(4-methoxy-benzyloxy)-4-phenylselanyl-butyl]-3,7-dimethyl-octa-3,6-dienoyl}-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-Benzyl-3-{(E)-(S)-2-[(1S,2R)-1-hydroxy-2-(4-methoxy-benzyloxy)-4-phenylselanyl-butyl]-3,7-dimethyl-octa-3,6-dienoyl}-oxazolidin-2-one
CAS No.:1054617-67-2
Molecular Formula:C₃₈H₄₅NO₆Se
Molecular Weight:690.738
Hs Code.:

Synonyms:(R)-4-Benzyl-3-{(E)-(S)-2-[(1S,2R)-1-hydroxy-2-(4-methoxy-benzyloxy)-4-phenylselanyl-butyl]-3,7-dimethyl-octa-3,6-dienoyl}-oxazolidin-2-one

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Chemical Property of (R)-4-Benzyl-3-{(E)-(S)-2-[(1S,2R)-1-hydroxy-2-(4-methoxy-benzyloxy)-4-phenylselanyl-butyl]-3,7-dimethyl-octa-3,6-dienoyl}-oxazolidin-2-one

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Technology Process of (R)-4-Benzyl-3-{(E)-(S)-2-[(1S,2R)-1-hydroxy-2-(4-methoxy-benzyloxy)-4-phenylselanyl-butyl]-3,7-dimethyl-octa-3,6-dienoyl}-oxazolidin-2-one

There total 11 articles about (R)-4-Benzyl-3-{(E)-(S)-2-[(1S,2R)-1-hydroxy-2-(4-methoxy-benzyloxy)-4-phenylselanyl-butyl]-3,7-dimethyl-octa-3,6-dienoyl}-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 364337-19-9
(2R)-2-p-methoxybenzyloxy-4-phenylselanylbutanal

: 364337-20-2
(4R)-4-benzyl-3-[(3E)-(3,7-dimethylocta-3,6-dienoyl)]-oxazolidin-2-one

: 1054617-67-2
(R)-4-Benzyl-3-{(E)-(S)-2-[(1S,2R)-1-hydroxy-2-(4-methoxy-benzyloxy)-4-phenylselanyl-butyl]-3,7-dimethyl-octa-3,6-dienoyl}-oxazolidin-2-one

Guidance literature:: (4R)-4-benzyl-3-[(3E)-(3,7-dimethylocta-3,6-dienoyl)]-oxazolidin-2-one; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

(2R)-2-p-methoxybenzyloxy-4-phenylselanylbutanal; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h; Further stages.;
DOI:10.1021/ol016343z

Reference yield:

: 16750-94-0
2,6-dimethyl-2,5-octadien-8-ol

: 1054617-67-2
(R)-4-Benzyl-3-{(E)-(S)-2-[(1S,2R)-1-hydroxy-2-(4-methoxy-benzyloxy)-4-phenylselanyl-butyl]-3,7-dimethyl-octa-3,6-dienoyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 35 percent / CrO₃; sulfuric acid / H₂O; acetone / 0.25 h / 0 °C

2.1: triethylamine / tetrahydrofuran / 0.5 h / -78 - 0 °C

3.1: 188 mg / tetrahydrofuran; hexane / 0.33 h / -78 °C

4.1: LDA / tetrahydrofuran; hexane / 0.75 h / -78 °C

4.2: tetrahydrofuran; hexane / 0.75 h / -78 °C

With chromium(VI) oxide; sulfuric acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; water; acetone;
DOI:10.1021/ol016343z

Reference yield:

: 1666-13-3
diphenyl diselenide

: 1054617-67-2
(R)-4-Benzyl-3-{(E)-(S)-2-[(1S,2R)-1-hydroxy-2-(4-methoxy-benzyloxy)-4-phenylselanyl-butyl]-3,7-dimethyl-octa-3,6-dienoyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium borohydride / dimethylformamide / 20 °C

1.2: dimethylformamide / 2 h / 80 °C

2.1: 18.7 g / diethyl ether / 20 °C

3.1: 70 percent / camphorsulfonic acid / CH₂Cl₂ / 24 h / 20 °C

4.1: 94 percent / DIBAH / toluene / 0.33 h / -78 °C

5.1: LDA / tetrahydrofuran; hexane / 0.75 h / -78 °C

5.2: tetrahydrofuran; hexane / 0.75 h / -78 °C

With sodium tetrahydroborate; camphor-10-sulfonic acid; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol016343z