1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylic acid lithium salt

Base Information

Chemical Name:1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylic acid lithium salt
CAS No.:1192829-31-4
Molecular Formula:C₂₆H₂₄ClN₄O₄*Li
Molecular Weight:498.895
Hs Code.:

Synonyms:1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylic acid lithium salt

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Chemical Property of 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylic acid lithium salt

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Technology Process of 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylic acid lithium salt

There total 9 articles about 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylic acid lithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192829-71-2
ethyl 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylate

: 1192829-31-4
1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylic acid lithium salt

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 3h;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1192829-31-4
1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylic acid lithium salt

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; HATU / 2.5 h / 20 - 130 °C / Microwave irradiation

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

3: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere

4: butan-1-ol / 2 h / 175 °C / Microwave irradiation

5: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 80 °C

With water; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; butan-1-ol;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1192829-31-4
1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylic acid lithium salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: water; sodium hydroxide / methanol / 20 °C

2.2: pH 1 - 2 / Acidification

3.1: triethylamine; HATU / 2.5 h / 20 - 130 °C / Microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

5.1: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere

6.1: butan-1-ol / 2 h / 175 °C / Microwave irradiation

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 80 °C

With water; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; sodium hydroxide; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;